MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, PR China.
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, PR China.
Curr Opin Chem Biol. 2023 Jun;74:102308. doi: 10.1016/j.cbpa.2023.102308. Epub 2023 Apr 21.
The realization that liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in cells has motivated efforts to modulate the condensation process of biomolecules. Increasing evidence shows that metals and inorganic molecules abundantly distributed in cells play important roles in the regulation of biomolecular condensation. Herein, we briefly reviewed the background of biomacromolecular phase separation and summarized the recent research progress on the roles of metals and inorganic molecules in regulating protein and nucleic acid phase separation in vitro and in cells.
液-液相分离（LLPS）是细胞中无膜隔间形成的基础，这一认识促使人们努力调节生物分子的凝聚过程。越来越多的证据表明，细胞中广泛分布的金属和无机分子在调节生物分子凝聚方面发挥着重要作用。本文简要回顾了生物大分子相分离的背景，并总结了近年来关于金属和无机分子在调节蛋白质和核酸体外及细胞内相分离的作用的研究进展。
