口服避孕药对血清催乳素的影响：126名正常绝经前女性的纵向研究。

Effect of oral contraceptives on serum prolactin: a longitudinal study in 126 normal premenopausal women.

作者信息

Hwang P L, Ng C S, Cheong S T

出版信息

Clin Endocrinol (Oxf). 1986 Feb;24(2):127-33. doi: 10.1111/j.1365-2265.1986.tb00754.x.

DOI:10.1111/j.1365-2265.1986.tb00754.x

Abstract

A prospective longitudinal study was carried out in 126 normal premenopausal women aged 18-34 years to determine the effect of oral contraceptives containing less than 50 micrograms of oestrogen on serum prolactin concentration. The mean prolactin concentration in patients receiving oral contraceptives (n = 80) rose from a control level of 8.9 ng/ml to 10.2 ng/ml at 3 months (P less than 0.05) and 10.9 ng/ml at 12 months (P less than 0.001). In a parallel group of patients (n = 46) who used intrauterine devices for contraception, no significant change in serum prolactin concentration was observed over the same period. It is concluded that currently available oral contraceptives have a small but significant stimulatory effect on prolactin secretion in normal women.

摘要

对126名年龄在18 - 34岁的绝经前正常女性进行了一项前瞻性纵向研究，以确定含雌激素低于50微克的口服避孕药对血清催乳素浓度的影响。接受口服避孕药的患者（n = 80）的平均催乳素浓度从对照水平8.9 ng/ml在3个月时升至10.2 ng/ml（P < 0.05），在12个月时升至10.9 ng/ml（P < 0.001）。在使用宫内节育器避孕的平行组患者（n = 46）中，同期血清催乳素浓度未观察到显著变化。得出结论：目前可用的口服避孕药对正常女性的催乳素分泌有微小但显著的刺激作用。