S. Fyodorov Eye Microsurgery Federal Institution, Moscow, Russia.
Department of Ophthalmology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia; and.
Cornea. 2024 Jan 1;43(1):45-51. doi: 10.1097/ICO.0000000000003279. Epub 2023 Apr 21.
The aim of this study was to report the midterm outcomes of glueless simple limbal epithelial transplantation (G-SLET) as a novel modification of limbal stem cell transplantation in patients with unilateral limbal stem cell deficiency (LSCD).
This was a single-center, retrospective, interventional case series. Analysis of the 6 months interim outcomes was performed for 11 patients with unilateral LSCD who underwent G-SLET without simultaneous keratoplasty. The primary outcome measure was clinical success, which was defined as a completely epithelialized, avascular, and stable corneal surface. Secondary outcome measures included LSCD staging, improvement in visual acuity, and corneal grading of the recipient eye before and after the intervention. Adverse events were monitored throughout the study period.
At 6-month follow-up, clinical success was achieved in 9 of the 11 cases (81.8%) and partial success was observed in 2 cases (18.2%). Among the patients in the cohort, 54.5% improved to stage 0 LSCD. Seven patients experienced enhancement in visual acuity. All corneal grading parameters improved significantly. Six adverse events were registered in 5 cases and were successfully managed. An extended scar in the donor eye was observed in 1 patient.
This study demonstrated the high efficacy and safety of the G-SLET technique in the management of unilateral LSCD. G-SLET should be considered as a viable alternative to the"classic" SLET technique, specifically in the geographic areas where the availability of the fibrin glue is limited due to regulatory, economical, or any other reasons.
本研究旨在报告无细胞黏合性简单角膜缘上皮移植术（G-SLET）作为一种新型角膜缘干细胞移植术改良方法治疗单侧角膜缘干细胞缺乏症（LSCD）的中期结果。
这是一项单中心、回顾性、干预性病例系列研究。对 11 例接受无细胞黏合性 G-SLET 治疗且未同时行角膜移植术的单侧 LSCD 患者进行了 6 个月的中期结果分析。主要结局指标为临床成功，定义为完全上皮化、无血管且角膜表面稳定。次要结局指标包括 LSCD 分期、视力改善以及干预前后受者眼的角膜分级。在整个研究期间监测不良事件。
在 6 个月的随访中，11 例中有 9 例（81.8%）达到临床成功，2 例（18.2%）为部分成功。在该队列的患者中，54.5%的患者改善为 0 期 LSCD。7 例患者视力提高。所有角膜分级参数均显著改善。5 例患者出现 6 种不良事件，并成功处理。1 例患者供体眼角膜出现扩展性瘢痕。
本研究表明 G-SLET 技术治疗单侧 LSCD 的疗效和安全性较高。G-SLET 应被视为“经典” SLET 技术的可行替代方法，特别是在由于监管、经济或任何其他原因导致纤维蛋白胶供应有限的地理区域。
