Chen Yu, Dang Haodan, Wu Xiaoqian, Zhang Zhuhua, Shi Xiaohua, Zhang Tao, Chen Xingming, Zhu Xiaoli, Su Tong, Wang Yunting, Hou Bo, Jin Zhengyu
Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuai Fu Yuan, Dong Cheng District, Beijing 100730, China.
Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, Fuxing Road 28, Beijing, China.
Heliyon. 2023 Mar 22;9(4):e14822. doi: 10.1016/j.heliyon.2023.e14822. eCollection 2023 Apr.
To investigate the correlation between parameters of PET/MR and the expression level of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinoma (HNSCC) and to evaluate diagnostic efficacy of independent and combined PET/MR parameters for the expression level of EGFR.
21 patients who had undergone PET/MR and been proven HNSCC pathologically were included in this retrospective study. The PET/MR sequences included 18-flurodeoxyglucose (F-FDG) PET, T1, T2-weighted imaging, DWI, ADC and DCE. Parameters including ADC from DWI, Ktrans, Ve, Kep from DCE, and SUV, SUV from PET were obtained. Immunohistochemical method was used to detect the expression level of EGFR. The associations between parameters of PET/MR and EGFR expression level were analyzed by Spearman's analysis. Logistic regression was utilized to establish the diagnostic model of EGFR expression level with PET/MR parameters. The efficacy of the independent and combined diagnostic model for EGFR expression level in HNSCC was analyzed by ROC curve. value ≤ 0.05 was considered statistically significant.
(1) Expression level of EGFR was correlated to SUV with correlation coefficient of 0.47 (p = 0.05). (2) There was significant difference of SUV between the EGFR high- and low-expression groups (p = 0.02). (3) Combination of PET/MR improved the diagnostic efficacy for expression level of EGFR, with AUC = 0.93.
There were different degrees of correlation between PET/MR parameters and EGFR expression level in HNSCC. Combination of PET/MR might improve diagnostic efficacy of EGFR expression level.
探讨头颈部鳞状细胞癌（HNSCC）中PET/MR参数与表皮生长因子受体（EGFR）表达水平之间的相关性，并评估PET/MR独立参数及联合参数对EGFR表达水平的诊断效能。
本回顾性研究纳入21例接受PET/MR检查且经病理证实为HNSCC的患者。PET/MR序列包括18F-氟脱氧葡萄糖（F-FDG）PET、T1加权成像、T2加权成像、扩散加权成像（DWI）、表观扩散系数（ADC）和动态对比增强（DCE）。获取的参数包括DWI的ADC值、DCE的传递常数（Ktrans）、血管外细胞外容积分数（Ve）、速率常数（Kep）以及PET的标准化摄取值（SUV）、最大标准化摄取值（SUV）。采用免疫组织化学方法检测EGFR的表达水平。通过Spearman分析评估PET/MR参数与EGFR表达水平之间的相关性。利用逻辑回归建立基于PET/MR参数的EGFR表达水平诊断模型。通过ROC曲线分析PET/MR独立诊断模型及联合诊断模型对HNSCC中EGFR表达水平的诊断效能。P值≤0.05认为差异具有统计学意义。
（1）EGFR表达水平与SUV相关，相关系数为0.47（P = 0.05）。（2）EGFR高表达组与低表达组的SUV存在显著差异（P = 0.02）。（3）PET/MR联合诊断提高了对EGFR表达水平的诊断效能，曲线下面积（AUC）= 0.93。
HNSCC中PET/MR参数与EGFR表达水平存在不同程度的相关性。PET/MR联合诊断可能提高EGFR表达水平的诊断效能。
