Chauviat Amandine, Meyer Thibault, Favre-Bonté Sabine
Université de Lyon, Université Claude Bernard Lyon 1, UMR CNRS 5557, UMR INRAe 1418, VetAgro Sup, Ecologie Microbienne, F-69622 Villeurbanne, France.
Heliyon. 2023 Mar 28;9(4):e14639. doi: 10.1016/j.heliyon.2023.e14639. eCollection 2023 Apr.
is a widely distributed bacterium found in natural, anthropized and clinical environments. The genome of this opportunistic pathogen of environmental origin includes a large number of genes encoding RND efflux pumps independently of the clinical or environmental origin of the strains. These pumps have been historically associated with the uptake of antibiotics and clinically relevant molecules because they confer resistance to many antibiotics. However, considering the environmental origin of , the ecological role of these pumps needs to be clarified. RND efflux systems are highly conserved within bacteria and encountered both in pathogenic and non-pathogenic species. Moreover, their evolutionary origin, conservation and multiple copies in bacterial genomes suggest a primordial role in cellular functions and environmental adaptation. This review is aimed at elucidating the ecological role of RND efflux pumps in the environmental context and providing an exhaustive description of the environmental niches of . By looking at the substrates and functions of the pumps, we propose different involvements and roles according to the adaptation of the bacterium to various niches. We highlight that i°) regulatory mechanisms and inducer molecules help to understand the conditions leading to their expression, and ii°) association and functional redundancy of RND pumps and other efflux systems demonstrate their complex role within cells. These observations emphasize that RND efflux pumps play a role in the versatility of
是一种广泛分布于自然、人为和临床环境中的细菌。这种环境来源的机会性病原体的基因组包含大量编码RND外排泵的基因，而与菌株的临床或环境来源无关。这些泵在历史上一直与抗生素和临床相关分子的摄取有关，因为它们赋予对许多抗生素的抗性。然而，考虑到的环境来源，这些泵的生态作用需要阐明。RND外排系统在细菌中高度保守，在致病和非致病物种中均有发现。此外，它们在细菌基因组中的进化起源、保守性和多个拷贝表明其在细胞功能和环境适应中具有原始作用。本综述旨在阐明RND外排泵在环境背景下的生态作用，并对的环境生态位进行详尽描述。通过研究泵的底物和功能，我们根据细菌对各种生态位的适应性提出了不同的参与方式和作用。我们强调：i）调节机制和诱导分子有助于理解导致其表达的条件，以及ii）RND泵与其他外排系统的关联和功能冗余证明了它们在细胞内的复杂作用。这些观察结果强调RND外排泵在的多功能性中发挥作用
