RND外排泵在囊性纤维化病原体耐药性中的作用
Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens.
作者信息
Scoffone Viola Camilla, Trespidi Gabriele, Barbieri Giulia, Irudal Samuele, Perrin Elena, Buroni Silvia
机构信息
Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
Department of Biology, University of Florence, 50019 Sesto Fiorentino, Italy.
出版信息
Antibiotics (Basel). 2021 Jul 15;10(7):863. doi: 10.3390/antibiotics10070863.
Abstract
Drug resistance represents a great concern among people with cystic fibrosis (CF), due to the recurrent and prolonged antibiotic therapy they should often undergo. Among Multi Drug Resistance (MDR) determinants, Resistance-Nodulation-cell Division (RND) efflux pumps have been reported as the main contributors, due to their ability to extrude a wide variety of molecules out of the bacterial cell. In this review, we summarize the principal RND efflux pump families described in CF pathogens, focusing on the main Gram-negative bacterial species (, , , ) for which a predominant role of RND pumps has been associated to MDR phenotypes.
摘要
耐药性是囊性纤维化（CF）患者极为关注的问题，因为他们经常需要接受反复且长期的抗生素治疗。在多重耐药（MDR）决定因素中，耐药-固氮-细胞分裂（RND）外排泵被认为是主要因素，因为它们能够将多种分子排出细菌细胞。在本综述中，我们总结了CF病原体中描述的主要RND外排泵家族，重点关注主要的革兰氏阴性菌物种（、、、），RND泵在这些细菌的MDR表型中起主要作用。
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