Zhang Yuan, Li Jie, Zhang Shu
Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao Yang Hospital, Capital Medical University, Beijing, China.
Front Med (Lausanne). 2023 Apr 5;10:1099685. doi: 10.3389/fmed.2023.1099685. eCollection 2023.
Malignant pleural mesothelioma (MPM) is a kind of pleural cancer characterized by low incidence but high invasiveness. There is heterogeneity in survival among patients with MPM. Inflammation-related and electrolyte laboratory variables were previously reported as potential predictors of survival. We evaluated the relationship between overall survival and pre-treatment biomarkers.
Patients diagnosed with MPM in Beijing Chaoyang Hospital for more than 10 years were screened for this study. All basic, clinical, radiologic and laboratory variables were collected. The COX univariable and multivariable analysis were used to explore prognostic related risk factors.
Ninety patients with MPM were included. The median follow-up of all patients was 57 months [interquartile range (IQR): 27-100 months]. The median survival time was 24 months (IQR: 12-52 months). Univariate survival analyses indicated that age, Eastern Cooperative Oncology Group Performance Status, treatment, erythrocyte sedimentation rate, calcium, lymphocyte, hemoglobin, platelet-to-lymphocyte ratio (PLR), and monocyte-to-white blood cell ratio (MWR) were significantly related to survival. Multivariable analysis demonstrated that age [hazard ratio (HR), 2.548; 95% confidence interval (CI) 1.145-5.666; = 0.022], calcium (HR, 0.480; 95% CI 0.270-0.855; = 0.013), PLR (HR, 2.152; 95% CI 1.163-3.981; = 0.015), and MWR (HR, 3.360; 95% CI 1.830-6.170; < 0.001) might have a significant impact on the prognosis.
Calcium, MWR, and PLR might be related to the prognosis of MPM patients. Analyzing the relationship between the results of inflammation-related and electrolyte laboratory variables in peripheral blood and prognosis could help clinicians evaluate the situation of patients.
恶性胸膜间皮瘤（MPM）是一种发病率低但侵袭性高的胸膜癌。MPM患者的生存存在异质性。炎症相关和电解质实验室变量此前被报道为生存的潜在预测指标。我们评估了总生存期与治疗前生物标志物之间的关系。
筛选出在北京朝阳医院诊断为MPM超过10年的患者进行本研究。收集所有基本、临床、放射学和实验室变量。采用COX单变量和多变量分析来探索预后相关危险因素。
纳入90例MPM患者。所有患者的中位随访时间为57个月[四分位间距（IQR）：27 - 100个月]。中位生存时间为24个月（IQR：12 - 52个月）。单变量生存分析表明，年龄、东部肿瘤协作组体能状态、治疗、红细胞沉降率、钙、淋巴细胞、血红蛋白、血小板与淋巴细胞比值（PLR）和单核细胞与白细胞比值（MWR）与生存显著相关。多变量分析显示，年龄[风险比（HR），2.548；95%置信区间（CI）1.145 - 5.666；P = 0.022]、钙（HR，0.480；95% CI 0.270 - 0.855；P = 0.013）、PLR（HR，2.152；95% CI 1.163 - 3.981；P = 0.015）和MWR（HR，3.360；95% CI 1.830 - 6.170；P < 0.001）可能对预后有显著影响。
钙、MWR和PLR可能与MPM患者的预后相关。分析外周血中炎症相关和电解质实验室变量结果与预后的关系有助于临床医生评估患者情况。
