Mohta Alpana, Nyati Asha, Mohta Achala, Ghiya Bhikam C, Mehta Rajesh D, Kumar Vanita
Departments of Dermatology, Venereology and Leprology, Sardar Patel Medical College, Bikaner, Rajasthan, India.
Departments of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India.
Indian Dermatol Online J. 2023 Mar 3;14(2):207-212. doi: 10.4103/idoj.idoj_449_22. eCollection 2023 Mar-Apr.
Owing to the myriad clinical presentations of COVID-19 vaccine-induced adverse events, clinicopathological correlation is the key to understanding the underlying pathophysiology of these reactions. However, there is still a dearth of such systematic studies across a wide spectrum of vaccine reactions.
This study provides a clinical and histopathological correlation of COVID-19 vaccine-induced mucocutaneous reactions.
The study population included all the individuals developing any form of self-reported mucocutaneous adverse events within 4 weeks of receiving the COVID-19 vaccine. The clinical and histopathological features were recorded.
A total of 126 cases were identified. Seven histopathological patterns were recognized. The most common histopathological feature was spongiotic dermatitis, seen in all the patients with "vaccine-related eruption of papules and plaques" (VREPP). Other patterns included lichenoid or interface dermatitis, dermal hypersensitivity reaction, leukocytoclastic vasculitis, subepidermal blistering, psoriasiform hyperplasia, and dermal granulomatous reaction.
Owing to such myriad clinical presentations, utilizing a histopathological classification could ease categorizing the vaccine-induced mucocutaneous eruptions.
由于新冠病毒疫苗诱导的不良事件临床表现多种多样，临床病理相关性是理解这些反应潜在病理生理学的关键。然而，针对广泛的疫苗反应进行的此类系统研究仍然匮乏。
本研究提供新冠病毒疫苗诱导的皮肤黏膜反应的临床与组织病理学相关性。
研究对象包括所有在接种新冠病毒疫苗后4周内出现任何形式自我报告的皮肤黏膜不良事件的个体。记录临床和组织病理学特征。
共识别出126例病例。确认了七种组织病理学模式。最常见的组织病理学特征是海绵状皮炎，见于所有患有“疫苗相关丘疹和斑块疹”（VREPP）的患者。其他模式包括苔藓样或界面性皮炎、真皮超敏反应、白细胞破碎性血管炎、表皮下水疱形成、银屑病样增生和真皮肉芽肿反应。
由于临床表现多种多样，采用组织病理学分类有助于对疫苗诱导的皮肤黏膜疹进行分类。
