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[皮肤病学中的当前疫苗接种与免疫策略]

[Current vaccination and immunization strategies in dermatology].

作者信息

Schrenker Steffen, Erpenbeck Luise

机构信息

Klinik für Hautkrankheiten, Universitätsklinikum Münster (UKM), Von-Esmarch-Str. 58, 48149, Münster, Deutschland.

出版信息

Dermatologie (Heidelb). 2024 Nov;75(11):889-901. doi: 10.1007/s00105-024-05400-0. Epub 2024 Oct 1.

Abstract

Vaccinations are an important pillar of public health. They have high benefits for individuals and society as a whole by specifically preventing or mitigating infectious diseases. In many cases, they offer benefits that go beyond protection against the disease in question, e.g., protective cardiovascular effects. Vaccination recommendations in Germany are drawn up by the Standing Committee on Vaccination (STIKO), while the European Medicines Agency (EMA) is responsible for the approval of vaccines in the EU. Vaccinations may be carried out by physicians regardless of their specialty. In dermatology, vaccinations against varicella (chickenpox), herpes zoster, and human papillomavirus are established. The development of vaccines against other dermatologically relevant diseases and cancer vaccines is the subject of intensive research. Particularly in the case of immunosuppression, the physician must also take into consideration which vaccinations are possible and useful or contraindicated. Type I or type IV allergies to components of vaccinations are very rare, but reactions at the injection site often occur as a dermatological side effect. Urticarial reactions are also possible, as does the worsening of underlying dermatological conditions such as psoriasis vulgaris.

摘要

疫苗接种是公共卫生的重要支柱。通过特异性预防或减轻传染病,疫苗接种对个人和整个社会都有很大益处。在许多情况下,疫苗接种的益处不止于预防所涉疾病,例如还具有心血管保护作用。德国的疫苗接种建议由疫苗接种常设委员会(STIKO)制定,而欧洲药品管理局(EMA)负责欧盟范围内疫苗的审批。无论医生的专业是什么,都可以进行疫苗接种。在皮肤科领域,水痘(带状疱疹)、带状疱疹和人乳头瘤病毒疫苗接种已确立。针对其他皮肤相关疾病的疫苗以及癌症疫苗的研发是深入研究的课题。特别是在免疫抑制的情况下,医生还必须考虑哪些疫苗接种是可行的、有用的或禁忌的。对疫苗成分的I型或IV型过敏非常罕见,但注射部位的反应经常作为皮肤副作用出现。荨麻疹反应也有可能发生,潜在的皮肤病如寻常型银屑病也可能加重。

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