Hurst L C, Badalamente M A, Oster Z H, Atkins H L, Weissberg D
Clin Orthop Relat Res. 1986 May(206):290-4.
The physical characteristics of a new tin radiopharmaceutical, 4+Sn-117m diethylenetriamine-pentaacetic acid (DTPA), may make this compound appropriate for orthopedic therapeutic application. The physical and biologic half-lives of this tracer are 14 and 7.8 days, respectively. The decay scheme consists of short-range tissue destroying beta, conversion, and Auger electrons, and a 159-keV gamma ray. Significantly, this compound has a high degree of affinity for newly calcified bone at the site of experimental burr holes in contrast to the adjacent bone marrow. Radioactive skeletal retention was one-half of whole body retention.
一种新型锡放射性药物，4+锡-117m二乙三胺五乙酸（DTPA）的物理特性，可能使该化合物适用于骨科治疗应用。这种示踪剂的物理半衰期和生物半衰期分别为14天和7.8天。衰变模式包括短程组织破坏β射线、内转换电子和俄歇电子，以及一条159千电子伏特的γ射线。值得注意的是，与相邻骨髓相比，该化合物对实验性毛刺孔部位新钙化的骨具有高度亲和力。放射性骨骼滞留量为全身滞留量的一半。
