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自体干细胞移植后中性粒细胞减少性小肠结肠炎:一份在ChatGPT协助下撰写的引人注目的临床病例报告

Neutropenic Enterocolitis Following Autologous Stem Cell Transplantation: A Compelling Clinical Case Report Written With the Assistance of ChatGPT.

作者信息

Milan-Ortiz Vanessa, Damughatla Anirudh R, Qazi Adam M, Kamatham Saivaishnavi, Oli Sharad, Koleti Pragna, Levine Diane L

机构信息

Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA.

Pulmonary Critical Care, Wayne State University Detroit Medical Center, Detroit, USA.

出版信息

Cureus. 2023 Mar 20;15(3):e36390. doi: 10.7759/cureus.36390. eCollection 2023 Mar.

Abstract

Neutropenic enterocolitis (NE) is a rare and life-threatening condition that typically occurs in patients with hematologic malignancies undergoing intensive chemotherapy, radiation therapy, or bone marrow transplant regimens, predisposing them to profound neutropenia. NE can have a nonspecific clinical presentation and mimic other gastrointestinal disorders such as appendicitis, diverticulitis, or inflammatory bowel disease but is associated with very high morbidity and mortality if not diagnosed and treated promptly. We present the case of a middle-aged female with a recent diagnosis of follicular lymphoma who developed neutropenic enterocolitis after undergoing induction chemotherapy for an autologous stem cell transplant (ASCT). In this article, we provide a literature review of neutropenic enterocolitis and highlight the importance of a prompt diagnosis and management, given its high mortality rate.

摘要

中性粒细胞减少性小肠结肠炎(NE)是一种罕见且危及生命的疾病,通常发生在接受强化化疗、放疗或骨髓移植方案的血液系统恶性肿瘤患者中,使他们易发生严重的中性粒细胞减少。NE的临床表现可能不具特异性,可类似于其他胃肠道疾病,如阑尾炎、憩室炎或炎症性肠病,但如果不及时诊断和治疗,其发病率和死亡率会非常高。我们报告一例近期诊断为滤泡性淋巴瘤的中年女性病例,该患者在接受自体干细胞移植(ASCT)诱导化疗后发生了中性粒细胞减少性小肠结肠炎。在本文中,鉴于中性粒细胞减少性小肠结肠炎的高死亡率,我们对其进行了文献综述,并强调了及时诊断和管理的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5eb7/10115743/06f4d79b6fb7/cureus-0015-00000036390-i01.jpg

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