A novel antibody to treat SOD1-related amyotrophic lateral sclerosis.
作者信息
Boulis Nicholas M, Donsante Anthony
机构信息
Department of Neurosurgery, Emory University, Atlanta, GA, USA.
出版信息
Mol Ther Methods Clin Dev. 2023 Apr 6;29:236-237. doi: 10.1016/j.omtm.2023.03.011. eCollection 2023 Jun 8.
Abstract
摘要
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Prion Properties of SOD1 in Amyotrophic Lateral Sclerosis and Potential Therapy.SOD1 在肌萎缩侧索硬化症中的朊病毒特性及潜在治疗策略。
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Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS.鞘内注射针对 SOD1 突变体错误折叠形式的单克隆抗体或其衍生 Fab 片段可延迟 ALS 小鼠模型的死亡率。
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