Ranganath Prajnya, Patil Mallikarjun
Department of Medical Genetics, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
J Pediatr Genet. 2021 Feb 17;12(2):163-166. doi: 10.1055/s-0041-1723959. eCollection 2023 Jun.
The "eye-of-the-tiger" sign in brain magnetic resonance imaging (MRI) is typically associated with neurodegeneration with brain iron accumulation disorders, especially pantothenate kinase-associated neurodegeneration. However, very similar neuroimaging findings may be seen in other neurodegenerative disorders involving the basal ganglia. We report here a patient with fucosidosis who had MRI brain findings closely resembling the "eye-of-the-tiger" sign.
脑磁共振成像(MRI)中的“虎眼征”通常与伴有脑铁沉积的神经退行性疾病相关,尤其是泛酸激酶相关神经退行性变。然而,在其他累及基底神经节的神经退行性疾病中也可能出现非常相似的神经影像学表现。我们在此报告一名岩藻糖苷贮积症患者,其脑部MRI表现与“虎眼征”极为相似。