邻苯二甲酸酯（PAEs）对新生儿的影响及致畸作用的相关方面。
Effects of phthalic acid esters (PAEs) on the neonate and aspects of teratogenic actions.
作者信息
Thomas J A, Wienckowski D B, Gillies B A, Thomas M J, Youkilis E J
出版信息
Environ Health Perspect. 1986 Mar;65:243-8. doi: 10.1289/ehp.8665243.
Abstract
A review of the literature reveals that several different phthalic acid esters (PAEs) are capable of causing testicular damage. Phthalate-induced zinc deficiency is consistent with germinal epithelial damage. Among experimental animals, mice perhaps show the greatest sensitivity to phthalate-induced terata, but high doses/exposure are required. Little toxicologic information is available with regard to phthalate-induced effects upon the neonate.
摘要
文献综述表明，几种不同的邻苯二甲酸酯（PAEs）能够导致睾丸损伤。邻苯二甲酸酯诱导的锌缺乏与生殖上皮损伤一致。在实验动物中，小鼠可能对邻苯二甲酸酯诱导的畸形表现出最大的敏感性，但需要高剂量/暴露。关于邻苯二甲酸酯对新生儿的影响，几乎没有毒理学信息。
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Some hazards in the manufacture and use of plastics.塑料制造与使用中的一些危害。
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Effect of testosterone and gonadotrophin injections on the sex organ development of zinc-deficient male rats.睾酮和促性腺激素注射对缺锌雄性大鼠性器官发育的影响。
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Teratogenic potential of di- and mono-(2-ethylhexyl)phthalate in mice.邻苯二甲酸二（2-乙基己基）酯和邻苯二甲酸单（2-乙基己基）酯对小鼠的致畸潜力。
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Embryotoxic effects of di-2-ethylhexyl phthalate (DEHP) and di-n-buty phthalate (DBP) in mice.邻苯二甲酸二（2-乙基己基）酯（DEHP）和邻苯二甲酸二正丁酯（DBP）对小鼠的胚胎毒性作用。
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Assessment of the teratogenic potential of plasma-soluble extracts of diethylhexyl phthalate plasticized polyvinyl chloride plastics in rats.邻苯二甲酸二乙酯增塑聚氯乙烯塑料的血浆可溶性提取物对大鼠致畸潜力的评估。
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Testicular atrophy induced by phthalic acid esters: effect on testosterone and zinc concentrations.邻苯二甲酸酯诱导的睾丸萎缩：对睾酮和锌浓度的影响。
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Effect of di-2-ethylhexyl phthalate in the female rat: inhibition of hepatic and adrenal sterologenesis in vitro.邻苯二甲酸二（2-乙基己基）酯对雌性大鼠的影响：体外抑制肝脏和肾上腺的甾体生成
Bull Environ Contam Toxicol. 1980 Jan;24(1):54-8. doi: 10.1007/BF01608075.
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Structure-activity requirements for the induction of testicular atrophy by butyl phthalates in immature rats: effect on testicular zinc content.邻苯二甲酸丁酯诱导未成熟大鼠睾丸萎缩的构效关系：对睾丸锌含量的影响
Adv Exp Med Biol. 1981;136 Pt A:445-52. doi: 10.1007/978-1-4757-0674-1_33.
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