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Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers.

作者信息

Leemann T, Dayer P, Meyer U A

出版信息

Eur J Clin Pharmacol. 1986;29(6):739-41. doi: 10.1007/BF00615971.

DOI:10.1007/BF00615971
PMID:3709620
Abstract
摘要

相似文献

1
Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers.单剂量奎尼丁治疗可抑制代谢活跃者体内美托洛尔的氧化。
Eur J Clin Pharmacol. 1986;29(6):739-41. doi: 10.1007/BF00615971.
2
Single-dose quinidine treatment inhibits mexiletine oxidation in extensive metabolizers of debrisoquine.
Life Sci. 1991;48(26):PL123-8. doi: 10.1016/0024-3205(91)90618-l.
3
Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes.利用奎尼丁抑制作用来确定司巴丁/异喹胍细胞色素P450在人肝微粒体对美托洛尔氧化中的作用。
J Pharmacol Exp Ther. 1988 Oct;247(1):242-7.
4
Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers.美托洛尔在异喹胍代谢快者和慢者中的差异立体选择性代谢。
Clin Pharmacol Ther. 1983 Dec;34(6):732-7. doi: 10.1038/clpt.1983.242.
5
Similar effect of oxidation deficiency (debrisoquine polymorphism) and quinidine on the apparent volume of distribution of (+/-)-metoprolol.
Eur J Clin Pharmacol. 1993;45(1):65-71. doi: 10.1007/BF00315352.
6
Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.有证据表明丝氨酸304并非细胞色素P450 2D6活性位点中的关键配体结合残基。
Biochem J. 2000 Feb 1;345 Pt 3(Pt 3):565-71.
7
Stereoselective metabolism of metoprolol in Caucasians and Nigerians--relationship to debrisoquine oxidation phenotype.美托洛尔在白种人和尼日利亚人中的立体选择性代谢——与异喹胍氧化表型的关系。
Br J Clin Pharmacol. 1989 May;27(5):613-6. doi: 10.1111/j.1365-2125.1989.tb03424.x.
8
Polymorphic metabolism of metoprolol: clinical studies.美托洛尔的多态性代谢：临床研究
Eur J Clin Pharmacol. 1985;28 Suppl:85-8. doi: 10.1007/BF00543716.
9
Inhibition of debrisoquine hydroxylation with quinidine in subjects with three or more functional CYP2D6 genes.在具有三个或更多功能性CYP2D6基因的受试者中，奎尼丁对异喹胍羟基化的抑制作用。
Br J Clin Pharmacol. 2000 Feb;49(2):180-4. doi: 10.1046/j.1365-2125.2000.00120.x.
10
Correlation between the metabolic ratios of debrisoquine and metoprolol in Turkish subjects.
Pharmacol Toxicol. 1994 Jul;75(1):62-4. doi: 10.1111/j.1600-0773.1994.tb00325.x.

引用本文的文献

1
A cross-sectional study on metoprolol concentrations in various biological samples and their inter-correlations.横断面研究不同生物样本中美托洛尔浓度及其相互关系。
BMC Pharmacol Toxicol. 2024 Aug 8;25(1):45. doi: 10.1186/s40360-024-00773-3.
2
Influence of CYP2D6-dependent metabolism on the steady-state pharmacokinetics and pharmacodynamics of metoprolol and nicardipine, alone and in combination.CYP2D6依赖性代谢对美托洛尔和尼卡地平单药及联合用药时稳态药代动力学和药效学的影响。
Br J Clin Pharmacol. 1993 Dec;36(6):531-8. doi: 10.1111/j.1365-2125.1993.tb00411.x.
3
A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment.

本文引用的文献

1
Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man.人体内去甲替林和安替比林清除率与异喹胍羟化作用的关系。
Life Sci. 1980 Nov 3;27(18):1673-7. doi: 10.1016/0024-3205(80)90642-6.
2
A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.对英国白人人群中异喹胍氧化遗传多态性的家系及群体研究。
J Med Genet. 1980 Apr;17(2):102-5. doi: 10.1136/jmg.17.2.102.
3
Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers.
接受美沙酮维持治疗患者的细胞色素P450 2D6基因型与表型之间的不一致性。
Br J Clin Pharmacol. 2003 Aug;56(2):220-4. doi: 10.1046/j.1365-2125.2003.01851.x.
4
Antiarrhythmic agents: drug interactions of clinical significance.抗心律失常药物：具有临床意义的药物相互作用
Drug Saf. 2000 Dec;23(6):509-32. doi: 10.2165/00002018-200023060-00003.
5
The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers.二氢可待因及其代谢产物二氢吗啡的内脏和躯体抗伤害感受作用。一项针对广泛代谢者和奎尼丁诱导的慢代谢者的交叉研究。
Br J Clin Pharmacol. 1998 Jun;45(6):575-81. doi: 10.1046/j.1365-2125.1998.00727.x.
6
[Pharmacology of tramadol].[曲马多的药理学]
Drugs. 1997;53 Suppl 2:18-24. doi: 10.2165/00003495-199700532-00006.
7
Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions.利用体外和体内数据评估代谢性药代动力学相互作用的可能性。
Clin Pharmacokinet. 1997 Mar;32(3):210-58. doi: 10.2165/00003088-199732030-00004.
8
Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone.美沙酮对人细胞色素P450 2D6（CYP2D6）的抑制作用。
Br J Clin Pharmacol. 1993 Jan;35(1):30-4. doi: 10.1111/j.1365-2125.1993.tb05666.x.
9
Similar effect of oxidation deficiency (debrisoquine polymorphism) and quinidine on the apparent volume of distribution of (+/-)-metoprolol.
Eur J Clin Pharmacol. 1993;45(1):65-71. doi: 10.1007/BF00315352.
10
Genetically determined adverse drug reactions involving metabolism.涉及代谢的基因决定的药物不良反应。
Drug Saf. 1993 Jul;9(1):60-77. doi: 10.2165/00002018-199309010-00006.
美托洛尔在异喹胍代谢快者和慢者中的差异立体选择性代谢。
Clin Pharmacol Ther. 1983 Dec;34(6):732-7. doi: 10.1038/clpt.1983.242.
4
Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme.通过使用针对类似大鼠酶产生的抗体来鉴定参与异喹胍和其他药物氧化的人肝脏细胞色素P-450。
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7348-52. doi: 10.1073/pnas.81.23.7348.
5
Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers.
Biochem Biophys Res Commun. 1984 Nov 30;125(1):374-80. doi: 10.1016/s0006-291x(84)80378-2.
6
Oxidation polymorphism has clinical relevance.氧化多态性具有临床相关性。
Lancet. 1984 Jul 28;2(8396):227. doi: 10.1016/s0140-6736(84)90513-0.
7
Debrisoquine-type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation.药物氧化的异喹胍型多态性：从人肝脏中纯化出对丁呋洛尔羟化具有高活性的一种细胞色素P450同工酶。
FEBS Lett. 1984 Aug 6;173(2):287-90. doi: 10.1016/0014-5793(84)80792-9.
8
Quinidine-induced rise in ajmaline plasma concentration.奎尼丁引起阿义马林血浆浓度升高。
J Pharm Pharmacol. 1984 Mar;36(3):202-4. doi: 10.1111/j.2042-7158.1984.tb06942.x.
9
Competitive inhibition of sparteine oxidation in human liver by beta-adrenoceptor antagonists and other cardiovascular drugs.β-肾上腺素受体拮抗剂及其他心血管药物对人肝脏中司巴丁氧化的竞争性抑制作用。
Life Sci. 1984 Jan 2;34(1):73-80. doi: 10.1016/0024-3205(84)90332-1.
10
Defective metabolism of metoprolol in poor hydroxylators of debrisoquine.在异喹胍羟化能力差的个体中，美托洛尔代谢存在缺陷。
Br J Clin Pharmacol. 1982 Aug;14(2):301-3. doi: 10.1111/j.1365-2125.1982.tb01982.x.