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西咪替丁和雷尼替丁对人肝微粒体中丙咪嗪去甲基化及去甲丙咪嗪羟基化的不同作用。

Differential effects of cimetidine and ranitidine on imipramine demethylation and desmethylimipramine hydroxylation by human liver microsomes.

作者信息

Spina E, Koike Y

出版信息

Eur J Clin Pharmacol. 1986;30(2):239-42. doi: 10.1007/BF00614311.

DOI:10.1007/BF00614311
PMID:3709653
Abstract

The effect of cimetidine and ranitidine on the demethylation of imipramine (IMI) and on the hydroxylation of desmethylimipramine (DMI) was studied in microsomes from four human livers. Cimetidine inhibited both demethylation of IMI and 2-hydroxylation of DMI, whilst the effect of ranitidine was not statistically significant. 2-hydroxylation of DMI is probably mediated by debrisoquine hydroxylase, a cytochrome P-450 isozyme that is monogenically controlled. The results suggest that cimetidine inhibits this enzyme.

摘要

在来自四个人类肝脏的微粒体中研究了西咪替丁和雷尼替丁对丙咪嗪（IMI）去甲基化以及去甲丙咪嗪（DMI）羟基化的影响。西咪替丁抑制了IMI的去甲基化和DMI的2-羟基化，而雷尼替丁的影响无统计学意义。DMI的2-羟基化可能由异喹胍羟化酶介导，异喹胍羟化酶是一种由单基因控制的细胞色素P-450同工酶。结果表明西咪替丁抑制了这种酶。

相似文献

1
Differential effects of cimetidine and ranitidine on imipramine demethylation and desmethylimipramine hydroxylation by human liver microsomes.西咪替丁和雷尼替丁对人肝微粒体中丙咪嗪去甲基化及去甲丙咪嗪羟基化的不同作用。
Eur J Clin Pharmacol. 1986;30(2):239-42. doi: 10.1007/BF00614311.
2
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本文引用的文献

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