Research laboratory "Heart Failure, LR12SP09", Hospital Farhat HACHED, Sousse, Tunisia.
Faculty of Medicine of Sousse, Department of Physiology, Sousse University, Sousse, Tunisia.
Libyan J Med. 2023 Dec;18(1):2204564. doi: 10.1080/19932820.2023.2204564.
Early detection of alteration of muscle strength, quantity, and quality, and sarcopenia is useful in non-cirrhotic chronic hepatitis B (NC-CHB) patients. Studies, which explored the handgrip strength (HGS) are scarce with questionable results, and no previous case-control study explored the presence of sarcopenia.The aim of this study was to assess the muscle strength [i.e.; HGS absolute (HGS), HGS/body mass index (BMI)], muscle quantity [i.e.; appendicular skeletal muscle (ASM), ASM/height, ASM/total body weight (TBW), ASM/BMI], and muscle quality [i.e.; HGS/total muscle mass (TMM), HGS/ASM] of NC-CHB patients.This was a case-control study. Cases ( = 26) were untreated NC-CHB patients, and controls ( = 28) were 'apparently' healthy participants. Muscle mass was estimated via the TMM (kg) and ASM (kg). Muscle strength was evaluated via the HGS data [i.e.; HGS (kg), HGS/BMI (m)]. Six variants of HGS were determined: highest values for the dominant and non-dominant hands, highest value between the two hands, averages of the three measurements for the two hands, and the average of the highest values of the two hands. Muscle quantity was expressed in three relative variants (ASM/height, ASM/TBW, and ASM/BMI). Muscle quality was evaluated via relative HGS data adjusted by muscle mass (i.e.; HGS/TMM, HGS/ASM). Probable and confirmed sarcopenia were retained in front of low muscle strength, and low muscle strength and muscle quantity or quality, respectively.There were no significant differences between controls and NC-CHB patients in values of muscle i) Strength whatever the HGS' mode of expression (e.g.; HGS/BMI: 1.59 ± 0.54 vs. 1.53 ± 0.54 m, = 0.622, respectively), ii) Quantity (e.g.; ASM/BMI: 0.79 ± 0.24 vs. 0.77 ± 0.23 m, = 0.883), and iii) Quality (e.g.; HGS/ASM: 2.00 ± 0.25 vs. 2.01 ± 0.41, = 0.952, respectively). One NC-CHB participant had a confirmed sarcopenia.To conclude, both controls and NC-CHB patients had similar HGS values. Only one NC-CHB patient had a confirmed sarcopenia.
早期发现肌肉力量、数量和质量的改变以及肌肉减少症对非肝硬化慢性乙型肝炎（NC-CHB）患者是有用的。探索握力（HGS）的研究很少，结果也存在疑问，而且以前没有病例对照研究探讨肌肉减少症的存在。本研究的目的是评估肌肉力量[即 HGS 绝对值（HGS）、HGS/体重指数（BMI）]、肌肉量[即四肢骨骼肌（ASM）、ASM/身高、ASM/总体重（TBW）、ASM/体重指数（BMI）]和肌肉质量[即 HGS/总肌肉量（TMM）、HGS/ASM]在 NC-CHB 患者中的情况。这是一项病例对照研究。病例组（n=26）为未经治疗的 NC-CHB 患者，对照组（n=28）为“明显”健康参与者。肌肉量通过 TMM（kg）和 ASM（kg）进行估计。肌肉力量通过 HGS 数据[即 HGS（kg）、HGS/BMI（m）]进行评估。确定了 HGS 的六个变体：优势手和非优势手的最高值、两只手之间的最高值、两只手的三次测量的平均值，以及两只手的最高值的平均值。肌肉量以三种相对变体表示（ASM/身高、ASM/TBW、ASM/BMI）。肌肉质量通过肌肉质量调整后的相对 HGS 数据进行评估[即 HGS/TMM、HGS/ASM]。在肌肉力量较低和肌肉力量、数量或质量较低的情况下，保留了可能和确诊的肌肉减少症。
对照组和 NC-CHB 患者在肌肉力量方面的差异无统计学意义，无论 HGS 的表达模式如何（例如，HGS/BMI：1.59±0.54 vs. 1.53±0.54 m， = 0.622），肌肉数量（例如，ASM/BMI：0.79±0.24 vs. 0.77±0.23 m， = 0.883）和肌肉质量（例如，HGS/ASM：2.00±0.25 vs. 2.01±0.41 m， = 0.952）。一名 NC-CHB 参与者被确诊为肌肉减少症。
总之，对照组和 NC-CHB 患者的 HGS 值相似。只有一名 NC-CHB 患者被确诊为肌肉减少症。
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