Bergaoui Jihene, Latiri Imed, Mrad Sawssen, Chaouch Houda, Amous Salma, Ben Abdallah Jihene, Ernez Hajri Samia, Ben Saad Helmi
Hospital Farhat HACHED, Research laboratory "Heart Failure, LR12SP09, Universite de Sousse Faculte de Medecine de Sousse, Sousse, Sousse, 4000, Tunisia.
Biochemistry Research Laboratory (LR18ES47), Farhat Hached University Hospital of Sousse, Sousse, Sousse, 4000, Tunisia.
F1000Res. 2025 Apr 8;14:98. doi: 10.12688/f1000research.160390.1. eCollection 2025.
Studies assessing sub-maximal aerobic capacity in non-cirrhotic chronic hepatitis B (CHB) patients are scarce. This study aimed to evaluate sub-maximal aerobic capacity in CHB patients compared to apparently healthy participants (control-group (CG)).
A 6-min walk test (6MWT) was performed. The 6-min walk distance (6MWD) was recorded, along with heart-rate (HR), oxy-hemoglobin saturation (SpO ), blood-pressure, and dyspnea ( ; visual analogue scale) at rest (Rest) and at the end (End) of the 6MWT. Additionally, the 6-min walk work (6MWW), and estimated cardiorespiratory and muscular chain age were calculated. Signs of physical intolerance were determined including abnormal 6MWD ( ; 6MWD < lower limit of normal), chronotropic insufficiency (ie ; HREnd < 60% of maximal predicted HR (MPHR)), high dyspnea ( ; dyspneaEnd > 5), and desaturation ( ; drop in SpO > 5 points).
Compared to the CG (n=28), the CHB-group (n=26) exhibited significantly lower 6MWD by 61 meters (8%), lower 6MWW by 10%, and lower HR by 21% (when expressed in bpm) and 17% (when expressed in %MPHR). The CHB-group, compared to the CG, included higher percentages of participants with chronotropic insufficiency and abnormal 6MWD (23.08% vs. 3.57%, and 34.61% vs. 3.57%, respectively). The CHB-group was 8.1 and 14.3 times more likely to have chronotropic insufficiency and abnormal 6MWD than the CG, respectively. CHB accelerated the aging of the cardiorespiratory and muscular chain by 11 years.
Non-cirrhotic CHB may contribute to reduced submaximal aerobic capacity and acceleration of cardiorespiratory and muscular chain aging.
评估非肝硬化慢性乙型肝炎（CHB）患者次最大有氧运动能力的研究较少。本研究旨在评估CHB患者与明显健康参与者（对照组（CG））相比的次最大有氧运动能力。
进行6分钟步行试验（6MWT）。记录6分钟步行距离（6MWD），以及静息时（休息）和6MWT结束时（结束）的心率（HR）、氧合血红蛋白饱和度（SpO）、血压和呼吸困难程度（；视觉模拟量表）。此外，计算6分钟步行功（6MWW）以及估计的心肺和肌肉链年龄。确定身体不耐受的体征，包括异常6MWD（；6MWD<正常下限）、变时性功能不全（即；运动结束时心率（HREnd）<最大预测心率（MPHR）的60%）、高度呼吸困难（；运动结束时呼吸困难程度>5）和血氧饱和度下降（；SpO下降>5个百分点）。
与CG组（n = 28）相比，CHB组（n = 26）的6MWD显著降低61米（8%），6MWW降低10%，HR降低21%（以bpm表示时）和17%（以%MPHR表示时）。与CG组相比，CHB组中变时性功能不全和异常6MWD的参与者百分比更高（分别为23.08%对3.57%和34.61%对3.57%）。CHB组出现变时性功能不全和异常6MWD的可能性分别是CG组的8.1倍和14.3倍。CHB使心肺和肌肉链的衰老加速了11年。
非肝硬化CHB可能导致次最大有氧运动能力降低以及心肺和肌肉链衰老加速。
