[Mechanisms of the damage to the liver monooxygenase systems in thermal ischemia].

It was shown in experiments in vitro that thermal ischemia of liver tissue leads to disorders in the function of membrane-bound microsomal monooxygenases. Disorders in the structural organization of membranes were also expressed in the inhibition of reactions of ascorbate-depending and fermentative peroxide oxidation of lipids and labilization of lysosomal membranes. Faults in the rate of amidopyrine n-demethylation and aniline n-hydroxylation correlate with the intensification of spontaneous peroxidation of lipids and activation of proteolytic processes in ischemia. The obtained data permitted to ground the approach to pharmacological prophylaxis of ischemic damages of liver microsomal monooxygenases.