[大鼠肝细胞内质网缺血后恢复的结构功能方面]
[Structural-functional aspects of the postischemic recovery of the hepatocyte endoplasmic network in rats].
作者信息
Sharapov V I, Sokirchenko I A, Grek O R, Shkurupiĭ V A, Dolgov A V
出版信息
Biull Eksp Biol Med. 1986 Mar;101(3):277-9.
PMID:3955208
Abstract
The experiments on rats have shown that total hepatic ischemia reduces the content of microsomal cytochromes P-450 and b5 and causes amidopyrine and aniline disturbances over a 2-3-week post-ischemic period. The analysis of hepatocyte ultrastructure has revealed the interdependence of structural and functional changes in endoplasmic reticulum during recovery period. The damage of monooxygenase inducibility correlated with stable decline in the number of fixed ribosomes in post-ischemic period.
摘要
对大鼠的实验表明，全肝缺血会降低微粒体细胞色素P - 450和b5的含量，并在缺血后2 - 3周内导致氨基比林和苯胺代谢紊乱。肝细胞超微结构分析揭示了恢复期内质网结构和功能变化之间的相互依赖性。单加氧酶诱导性的损伤与缺血后固定核糖体数量的持续下降相关。
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