腐胺可能是6-磷酸葡萄糖脱氢酶的天然刺激物。

Putrescine may be a natural stimulator of glucose-6-phosphate dehydrogenase.

作者信息

Dodds R A, Dunham J, Bitensky L, Chayen J

出版信息

FEBS Lett. 1986 May 26;201(1):105-8. doi: 10.1016/0014-5793(86)80579-8.

Abstract

The possible relationship between pyridoxal phosphate-dependent ornithine decarboxylase (ODC) activity and glucose-6-phosphate dehydrogenase (G6PD) activity has been studied in the osteoblasts of the growth-plate of metatarsals of rats fed a pyridoxine-deficient diet, which caused depressed G6PD levels. The G6PD activity was fully restored when it was assayed in the presence of putrescine. It is suggested that this relationship may account for the correlation generally found between growth and ODC activity.

摘要

在喂食缺乏维生素B6饮食的大鼠跖骨生长板成骨细胞中，研究了磷酸吡哆醛依赖性鸟氨酸脱羧酶（ODC）活性与葡萄糖-6-磷酸脱氢酶（G6PD）活性之间的可能关系，该饮食导致G6PD水平降低。当在腐胺存在下进行测定时，G6PD活性完全恢复。有人认为这种关系可能解释了生长与ODC活性之间普遍存在的相关性。