Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
PLoS One. 2023 Apr 25;18(4):e0284584. doi: 10.1371/journal.pone.0284584. eCollection 2023.
Absorbable magnesium (Mg) stents have an attractive biocompatibility and rapid degradation rate, but their degradable behavior and efficacy in the Eustachian tube (ET) have not yet been investigated. In this study, the degradable behavior of the Mg stent in artificial nasal mucus was evaluated. The Mg stents in the porcine ET model were also investigated to evaluate their safety and efficacy. Four Mg stents were placed into the four ETs of two pigs. The mass loss rate of the Mg stents gradually decreased over time. The decrease rates were 30.96% at one week, 49.00% at two weeks, and 71.80% at four weeks. On the basis of histological findings, the thickness of submucosal tissue hyperplasia and the degree of inflammatory cell infiltration significantly decreased at four weeks compared with two weeks. Biodegradation of the Mg stent occurred before tissue proliferative reactions, and the ET patency was successfully maintained without stent-induced tissue hyperplasia at four weeks. The Mg stent that biodegrades rapidly seems to be effective and safe in porcine ET. Further investigation is required to verify the optimal stent shape and indwell period in the ET.
可吸收镁（Mg）支架具有良好的生物相容性和快速降解率，但它们在咽鼓管（ET）中的降解行为和效果尚未得到研究。本研究评估了 Mg 支架在人工鼻黏液中的降解行为。还研究了 Mg 支架在猪 ET 模型中的安全性和有效性。将四个 Mg 支架放置在两只猪的四个 ET 中。Mg 支架的质量损失率随时间逐渐降低。一周时为 30.96%，两周时为 49.00%，四周时为 71.80%。基于组织学发现，与两周时相比，四周时黏膜下组织增生的厚度和炎症细胞浸润的程度显著降低。Mg 支架的降解发生在组织增殖反应之前，并且在四周时成功维持了 ET 通畅，没有支架引起的组织增生。快速降解的 Mg 支架在猪 ET 中似乎是有效和安全的。需要进一步研究以验证 ET 中最佳的支架形状和留置时间。
