Department of Pharmaceutics, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ther Deliv. 2023 Feb;14(2):121-138. doi: 10.4155/tde-2022-0072. Epub 2023 Apr 26.
Electrospraying (ELS) was used to prepare micronized ibuprofen-isonicotinamide cocrystal (IBU-INA-ELS) and its properties were compared with the solvent evaporated cocrystal (IBU-INA-SE). Solid-state characterization of crystalline phase, production yield, particle size, powder flow, wettability, solution mediated phase transformation (SMPT), and dissolution rate were measured. The ELS produced phase pure particles of IBU-INA with a size of 1.46 μm and yield of 72.3%. This cocrystal improved the intrinsic dissolution rate and powder dissolution rate of IBU by 3.6- and 1.7-fold, respectively. Our experiments showed that the dissolution of IBU-INA was affected by particle size, solubility, SMPT and wettability. ELS produced micronized cocrystals for improving dissolution of ibuprofen with a high yield in a single step and mild conditions.
电喷雾（ELS）被用于制备微米级布洛芬-异烟酰胺共晶（IBU-INA-ELS），并将其性质与溶剂蒸发共晶（IBU-INA-SE）进行了比较。对结晶相、产率、粒径、粉末流动、润湿性、溶液介导的相转变（SMPT）和溶解速率进行了固态特性表征。ELS 生产出了尺寸为 1.46μm、产率为 72.3%的 IBU-INA 纯相颗粒。该共晶将 IBU 的固有溶解速率和粉末溶解速率分别提高了 3.6 倍和 1.7 倍。我们的实验表明，IBU-INA 的溶解受到粒径、溶解度、SMPT 和润湿性的影响。ELS 一步法、温和条件下高产率制备微米级共晶以提高布洛芬的溶解速率。
