红细胞衰老过程中膜蛋白的交联
Crosslinking of membrane proteins during erythrocyte ageing.
作者信息
Gaczyńska M, Bartosz G
出版信息
Int J Biochem. 1986;18(4):377-82. doi: 10.1016/0020-711x(86)90044-3.
PMID:3709928
Abstract
Membrane proteins of bovine erythrocytes were crosslinked with cupric di(1,10-phenanthroline) and analysed by one-dimensional and two-dimensional SDS-polyacrylamide gel electrophoresis. An increase in crosslinking of the Band 3 protein and of spectrin was found with increasing erythrocyte age suggesting an increased aggregation of main membrane proteins in aged erythrocytes.
摘要
牛红细胞的膜蛋白用二（1,10 - 菲咯啉）铜进行交联，并通过一维和二维SDS - 聚丙烯酰胺凝胶电泳进行分析。随着红细胞年龄的增加，发现带3蛋白和血影蛋白的交联增加，这表明衰老红细胞中主要膜蛋白的聚集增加。
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