Hall W G, Browde J A
Dev Psychobiol. 1986 May;19(3):211-22. doi: 10.1002/dev.420190307.
Unlike infant rats, which show deprivation-related ingestion in several different test situations, infant mice appeared to be relatively unwilling to feed independently of suckling until 12 days of age. We tested mouse pups that were deprived (of food, water, suckling, and maternal care) for 1, 7, or 24 hr in ingestive tests in which a milk diet was spread on the floor of their test container (Experiment 1). Pups at 3, 6, and 9 days of age consumed small amounts of the diet and showed little increase in intake when deprivation was increased. In contrast (and like rat pups of all ages), mouse pups 12 and 15 days of age actively ingested the diet and increased their intake with increased deprivation. Six-day-old mouse pups were similarly unwilling to ingest a 5% sucrose solution, though 12-day-old pups showed deprivation-related intake (Experiment 2). Cellular dehydration (produced by hypertonic saline injection), a potent stimulus for ingestion in infant rats, did not stimulate ingestion in mice younger than 12 days of age (Experiment 3). Finally, when ingestion was tested with diet infusions made through oral cannulas, mouse pups at 6 and 9 days of age showed only a slight increase in intake with increased deprivation. However, by 12 days of age, pups' ingestion increased markedly with deprivation (Experiment 4). Thus, mouse pups seem to be very different from rat pups with respect to the early existence of ingestive systems. The neural substrates for the ingestive responses that subserve independent ingestion are only minimally present in infant mice or are somehow inhibited.
与在几种不同测试情境中表现出与剥夺相关摄食行为的幼鼠不同，幼鼠在12日龄之前似乎相对不愿意独立于吮乳行为进行进食。我们对在摄食测试中被剥夺（食物、水、吮乳和母性照料）1小时、7小时或24小时的幼鼠进行了测试，在这些测试中，一种奶类食物被铺洒在它们测试容器的底部（实验1）。3日龄、6日龄和9日龄的幼鼠摄入少量食物，并且当剥夺程度增加时摄入量几乎没有增加。相比之下（并且与所有年龄段的幼鼠一样），12日龄和15日龄的幼鼠积极摄入食物，并且随着剥夺程度的增加而增加摄入量。6日龄的幼鼠同样不愿意摄入5%的蔗糖溶液，不过12日龄的幼鼠表现出与剥夺相关的摄入量（实验2）。细胞脱水（通过注射高渗盐水产生），这是幼鼠摄食行为的一种有效刺激，在12日龄以下的幼鼠中并不会刺激摄食行为（实验3）。最后，当通过口腔插管进行食物灌注来测试摄食行为时，6日龄和9日龄的幼鼠随着剥夺程度的增加摄入量仅略有增加。然而，到12日龄时，幼鼠的摄入量随着剥夺程度的增加而显著增加（实验4）。因此，在摄食系统的早期存在方面，幼鼠似乎与幼鼠有很大不同。支持独立摄食行为的摄食反应的神经基质在幼鼠中仅少量存在，或者以某种方式受到抑制。
