Baggett J M, Berndt W O
Fundam Appl Toxicol. 1986 Jan;6(1):98-104. doi: 10.1016/0272-0590(86)90268-x.
The treatment of rats with single subcutaneous (sc) doses of mercuric chloride (4 mg/kg) plus potassium dichromate (10 mg/kg) resulted in greater effects on water consumption, urine volume, body weight, and urinary electrolyte excretion than produced by mercuric chloride alone. The dose of potassium dichromate alone had no effects on renal function. Urine volume at 6 hr was increased twofold over mercuric chloride alone. Similarly, potassium excretion by these animals at 6 hr was significantly decreased compared to controls. These animals were oliguric by 24 hr after the injection. Urine osmolality of rats receiving the combination of the metals remained lower than controls throughout the 4-day experimental period. Measurement of renal arterial blood flow by electromagnetic flow probe after subcutaneous injection of saline, mercuric chloride (4 mg/kg), potassium dichromate (10 mg/kg), or the combination, produced no change over a 2.5-hr period, at 24 hr, and at 48 hr, and the glomerular filtration rate (GFR) of these rats was not affected over the same period of time.
给大鼠单次皮下注射氯化汞（4毫克/千克）加二氯酸钾（10毫克/千克），相较于单独使用氯化汞，对水消耗、尿量、体重及尿电解质排泄的影响更大。单独使用二氯酸钾剂量对肾功能无影响。6小时时尿量比单独使用氯化汞增加了两倍。同样，与对照组相比，这些动物在6小时时钾排泄显著减少。注射后24小时这些动物出现少尿。在整个4天的实验期内，接受金属组合的大鼠尿渗透压仍低于对照组。皮下注射生理盐水、氯化汞（4毫克/千克）、二氯酸钾（10毫克/千克）或其组合后，用电磁流量探头测量肾动脉血流量，在2.5小时、24小时和48小时期间均无变化，且这些大鼠的肾小球滤过率（GFR）在同一时间段内未受影响。
