The Pathogen and Microbiome Institute, Northern Arizona University, 1395 S Knoles Dr., Bldg 56 Ste 210, Flagstaff, AZ 86011, USA.
The Pathogen and Microbiome Institute, Northern Arizona University, 1395 S Knoles Dr., Bldg 56 Ste 210, Flagstaff, AZ 86011, USA; Nùcleo de Medicina Tropical, University of Brasilia, Universitário Darcy Ribeiro, s/n -Asa Norte, Brasília, DF 70910-900, Brazil.
Fungal Genet Biol. 2023 Jun;167:103797. doi: 10.1016/j.fgb.2023.103797. Epub 2023 Apr 24.
Life-threatening infections caused by fungi in the order Onygenales have been rising over the last few decades. Increasing global temperature due to anthropogenic climate change is one potential abiotic selection pressure that may explain the increase in infections. The generation of genetically novel offspring with novel phenotypes through the process of sexual recombination could allow fungi to adapt to changing climate conditions. The basic structures associated with sexual reproduction have been identified in Histoplasma, Blastomyces, Malbranchea, and Brunneospora. However, for Coccidioides and Paracoccidioides, the actual structural identification of these processes has yet to be identified despite having genetic evidence that suggests sexual recombination is occurring in these organisms. This review highlights the importance of assessing sexual recombination in the order Onygenales as a means of understanding the mechanisms these organisms might employ to enhance fitness in the face of a changing climate and provides details regarding the known reproductive mechanisms in the Onygenales.
过去几十年来，由小囊菌目真菌引起的危及生命的感染一直在增加。人为气候变化导致的全球温度升高是可能导致感染增加的一种潜在非生物选择压力。通过有性重组过程产生具有新表型的遗传新颖后代，真菌可以适应不断变化的气候条件。在组织胞浆菌、芽生菌、Malbranchea 和 Brunneospora 中已经确定了与有性生殖相关的基本结构。然而，对于球孢子菌和副球孢子菌，尽管有遗传证据表明这些生物体中正在发生有性重组，但这些过程的实际结构鉴定尚未确定。本文综述了评估小囊菌目真菌有性重组的重要性，因为这是了解这些生物体在面对气候变化时可能采用的增强适应性的机制的一种手段，并提供了有关小囊菌目已知生殖机制的详细信息。
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