Dukik Karolina, Muñoz Jose F, Jiang Yanping, Feng Peiying, Sigler Lynne, Stielow J Benjamin, Freeke Joanna, Jamalian Azadeh, Gerrits van den Ende Bert, McEwen Juan G, Clay Oliver K, Schwartz Ilan S, Govender Nelesh P, Maphanga Tsidiso G, Cuomo Christina A, Moreno Leandro F, Kenyon Chris, Borman Andrew M, de Hoog Sybren
CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands.
Mycoses. 2017 May;60(5):296-309. doi: 10.1111/myc.12601. Epub 2017 Feb 7.
Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia. Another novel dimorphic pathogen, producing broad-based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces, and is described as Blastomyces percursus.
最近发现的具有热双态酵母样阶段的新型系统性真菌病原体对阿耶洛菌科目前的分类法提出了挑战，该科目前包括芽生菌属、埃蒙斯菌属、埃蒙斯小菌属、螺旋果菌属、组织胞浆菌属、拉卡菌属和副球孢子菌属。我们的形态学、系统发育和系统基因组分析表明了物种关系及其特定表型，明确了属的界限，并提供了首个带注释的基因组组装体，以支持对两个新物种的描述。一个新属Emergomyces包含巴氏埃蒙斯菌作为模式种，以及新物种非洲Emergomyces，它是南非一系列播散性感染病例的病原体。这两个物种在37°C时产生在狭窄基部出芽的小酵母细胞，并且缺乏典型的与埃蒙斯菌属相关的厚垣孢子。另一种新型双态病原体在37°C时产生基部较宽的出芽细胞，且发生在北美以外地区，经证明属于芽生菌属，被描述为前驱芽生菌。
