Guangxi University of Chinese Medicine, Nanning City, Guangxi Zhuang Autonomous Region 530001, China.
Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning City, Guangxi Zhuang Autonomous Region 530011, China.
Hum Immunol. 2023 May-Jul;84(5-7):327-336. doi: 10.1016/j.humimm.2023.04.003. Epub 2023 Apr 24.
Systemic lupus erythematosus (SLE), an autoimmune disease affecting multiple organs and tissues, is often complicated by musculoskeletal diseases. T helper cells (Th) play an important role in mediating lupus. With the rise of osteoimmunology, more studies have shown shared molecules and interactions between the immune system and bones. Th cells are vital in the regulation of bone metabolism by directly or indirectly regulating bone health by secreting various cytokines. Therefore, by describing the regulation of Th cells (including Th1, Th2, Th9, Th17, Th22, regulatory T cells (Treg), and follicular T helper cells (Tfh) in bone metabolism in SLE, this paper offers certain theoretical support for abnormal bone metabolism in SLE and provides new prospects for future drug development.
系统性红斑狼疮（SLE）是一种影响多个器官和组织的自身免疫性疾病，常伴有肌肉骨骼疾病。辅助性 T 细胞（Th）在介导狼疮中起着重要作用。随着骨免疫学的兴起，越来越多的研究表明免疫系统和骨骼之间存在共同的分子和相互作用。Th 细胞通过分泌各种细胞因子直接或间接地调节骨骼健康，对骨代谢的调节起着至关重要的作用。因此，通过描述 Th 细胞（包括 Th1、Th2、Th9、Th17、Th22、调节性 T 细胞（Treg）和滤泡辅助 T 细胞（Tfh）在 SLE 中骨代谢的调节，本文为 SLE 中异常骨代谢提供了一定的理论支持，并为未来药物开发提供了新的前景。
