Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Mediators Inflamm. 2023 Apr 17;2023:6210885. doi: 10.1155/2023/6210885. eCollection 2023.
Intervertebral disc degeneration (IDD) is a major contributor to back, neck, and radicular pain. It is related to changes in tissue structure and function, including the breakdown of the extracellular matrix (ECM), aging, apoptosis of the nucleus pulposus, and biomechanical tissue impairment. Recently, an increasing number of studies have demonstrated that inflammatory mediators play a crucial role in IDD, and they are being explored as potential treatment targets for IDD and associated disorders. For example, interleukins (IL), tumour necrosis factor- (TNF-), chemokines, and inflammasomes have all been linked to the pathophysiology of IDD. These inflammatory mediators are found in high concentrations in intervertebral disc (IVD) tissues and cells and are associated with the severity of LBP and IDD. It is feasible to reduce the production of these proinflammatory mediators and develop a novel therapy for IDD, which will be a hotspot of future research. In this review, the effects of inflammatory mediators in IDD were described.
椎间盘退变（IDD）是导致背痛、颈痛和神经根痛的主要原因。它与组织结构和功能的变化有关，包括细胞外基质（ECM）的破坏、衰老、髓核细胞凋亡和生物力学组织损伤。最近，越来越多的研究表明，炎症介质在 IDD 中起着至关重要的作用，它们被探索为 IDD 和相关疾病的潜在治疗靶点。例如，白细胞介素（IL）、肿瘤坏死因子-（TNF-）、趋化因子和炎性小体都与 IDD 的病理生理学有关。这些炎症介质在椎间盘（IVD）组织和细胞中含量较高，与 LBP 和 IDD 的严重程度相关。减少这些促炎介质的产生并开发一种新的 IDD 治疗方法是可行的，这将成为未来研究的热点。在这篇综述中，描述了炎症介质在 IDD 中的作用。
