结膜下给药后兔眼房水和角膜中环孢素的浓度。注射解剖部位的重要性。

Ciclosporin concentration in the rabbit aqueous humor and cornea following subconjunctival administration. Importance of anatomical site of injection.

作者信息

Behrens-Baumann W, Theuring S, Frey B, Frey F, Sostmann H, Bircher J

出版信息

Graefes Arch Clin Exp Ophthalmol. 1986;224(4):368-70. doi: 10.1007/BF02150031.

Abstract

The model compound lidocaine was used in the rabbit to investigate different sites of subconjunctival injection for the achievement of reproducible drug concentrations in the aqueous humor. Only epibulbar injections were satisfactory, but not parabulbar or injections under the lower fornix. After epibulbar administration of 0.8 ml 5% ciclosporin, median concentrations in the aqueous humor were 360, 700 and 200 ng/ml after 2, 8, and 24 h, respectively. Corresponding levels in the cornea were 32, 27, and 12 ng/ml. It appears that drug concentrations resulting from epibulbar injections may be therapeutically useful.

摘要

使用模型化合物利多卡因在兔子身上研究结膜下注射的不同部位，以实现在房水中获得可重复的药物浓度。只有眼球表面注射是令人满意的，而球旁注射或下穹窿下注射则不然。眼球表面给予0.8 ml 5%环孢素后，房水中的中位浓度在2、8和24小时后分别为360、700和200 ng/ml。角膜中的相应水平分别为32、27和12 ng/ml。看来眼球表面注射产生的药物浓度可能具有治疗作用。