Alexander Dheeraj, Abdelazeem Basel, Alnounou Mustafa
Internal Medicine, McLaren Health Care, Flint/Michigan State University, Flint, USA.
Gastroenterology, McLaren Health Care, Flint/Michigan State University, Flint, USA.
Cureus. 2023 Mar 25;15(3):e36660. doi: 10.7759/cureus.36660. eCollection 2023 Mar.
Olmesartan is a relatively new angiotensin receptor blocker used widely to control hypertension. Cases have been reported previously of enteropathy induced by olmesartan. Here, the authors report a case of olmesartan-induced ischemic enteritis complicated by bowel perforation. A 52-year-old male patient, during the treatment with olmesartan, developed severe abdominal pain of five-day duration. He underwent exploratory laparotomy for bowel perforation and surgical resection of the ischemic bowel segment. On a two-month follow-up after the discontinuation of olmesartan and the emergency surgery, the patient was symptom-free and functioning well. This rare report focuses on ischemic enteritis associated with olmesartan, describes the symptoms, and records the progression of this side effect and the corresponding treatment. Our case aims to raise awareness amongst physicians about the possibility of this severe complication and to point out that more research is still needed on its pathophysiology to better understand this drug.
奥美沙坦是一种相对较新的血管紧张素受体阻滞剂，广泛用于控制高血压。此前已有奥美沙坦诱发肠病的病例报道。在此，作者报告一例奥美沙坦诱发的缺血性肠炎并伴有肠穿孔的病例。一名52岁男性患者在接受奥美沙坦治疗期间，出现了持续五天的严重腹痛。他因肠穿孔接受了剖腹探查术，并对缺血性肠段进行了手术切除。在停用奥美沙坦并进行急诊手术后的两个月随访中，患者无症状且功能良好。这一罕见报告聚焦于与奥美沙坦相关的缺血性肠炎，描述了症状，并记录了这种副作用的进展及相应治疗。我们的病例旨在提高医生对这种严重并发症可能性的认识，并指出仍需要对其病理生理学进行更多研究，以更好地了解这种药物。
