Harrisingh Kamahl, Cu Cameron, Le Marjolein Le, Benhayon Daniel
Internal Medicine, Memorial Healthcare System, Hollywood, USA.
Cardiology, Memorial Healthcare, Pembroke Pines, USA.
Cureus. 2023 Mar 24;15(3):e36650. doi: 10.7759/cureus.36650. eCollection 2023 Mar.
Our case report highlights the importance of understanding various mechanisms of an atrioventricular block (AVB) and recognizing potential iatrogenic culprits. Despite the prevalent use of second-generation antipsychotics and the growing popularity of long-acting formulations, it is not routinely recognized as a cause for AVB. Second-generation antipsychotics such as risperidone have a dose-dependent pro-arrhythmic effect and are known to cause first-degree AVB. Our case presents an opportunity to recognize an unappreciated cause for AVB and switch to safer alternatives. In the era of long-acting injectables, it is important to monitor for these effects prior to escalating doses and risking high-degree AVB.
我们的病例报告强调了理解房室传导阻滞（AVB）的各种机制以及识别潜在医源性病因的重要性。尽管第二代抗精神病药物普遍使用且长效制剂越来越受欢迎，但它通常不被认为是导致AVB的原因。利培酮等第二代抗精神病药物具有剂量依赖性的促心律失常作用，已知会导致一度AVB。我们的病例提供了一个机会，来认识到一种未被重视的AVB病因，并转而使用更安全的替代药物。在长效注射剂的时代，在增加剂量并冒着发生高度AVB风险之前监测这些效应很重要。
