Kaye S B, Davies E
Gynecol Oncol. 1986 Jun;24(2):261-4. doi: 10.1016/0090-8258(86)90035-1.
Two cases of advanced granulosa cell tumor are described, in both of which chemotherapy comprising cyclophosphamide, adriamycin, and cis-platinum resulted in an objective partial response with marked symptomatic improvement. In one case the response continues at 12 months, in the other the response lasted for 5 months. In both cases elevated serum estradiol levels fell during treatment. A literature review reveals two previous cases in which this combination has been reported as being effective in advanced granulosa cell tumor, but this is the first report of the use of serum estradiol as a tumor marker.
本文描述了两例晚期颗粒细胞瘤患者，二者均接受了包含环磷酰胺、阿霉素和顺铂的化疗，化疗后均出现了客观的部分缓解，症状显著改善。其中一例患者在12个月时仍持续缓解，另一例患者的缓解持续了5个月。两例患者在治疗期间血清雌二醇水平均下降。文献综述显示，此前已有两例报告称该联合化疗方案对晚期颗粒细胞瘤有效，但这是首次报告将血清雌二醇用作肿瘤标志物。
