Cyclophosphamide, adriamycin, and cis-platinum for the treatment of advanced granulosa cell tumor, using serum estradiol as a tumor marker.

Two cases of advanced granulosa cell tumor are described, in both of which chemotherapy comprising cyclophosphamide, adriamycin, and cis-platinum resulted in an objective partial response with marked symptomatic improvement. In one case the response continues at 12 months, in the other the response lasted for 5 months. In both cases elevated serum estradiol levels fell during treatment. A literature review reveals two previous cases in which this combination has been reported as being effective in advanced granulosa cell tumor, but this is the first report of the use of serum estradiol as a tumor marker.