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用于医院隐私帘的单宁基杀菌涂层。

Tannin-Based Microbicidal Coatings for Hospital Privacy Curtains.

作者信息

Widsten Petri, Salo Satu, Niemelä Klaus, Helin Hanna, Salonen Minna, Alakomi Hanna-Leena

机构信息

VTT Technical Research Centre of Finland Ltd., Tietotie 2, 02150 Espoo, Finland.

FIMLAB Laboratoriot Ltd., Arvo Ylpön katu 4, 33520 Tampere, Finland.

出版信息

J Funct Biomater. 2023 Mar 27;14(4):187. doi: 10.3390/jfb14040187.

DOI:10.3390/jfb14040187
PMID:37103276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10144558/
Abstract

The goal of this study was to develop a sustainable, tannin-based option for silver-based and other current antimicrobial solutions for hospital privacy curtains. Commercial tree-derived tannins were characterized and their in vitro antibacterial properties against and were determined. Hydrolysable tannins showed greater antibacterial efficacy than condensed tannins but differences in antibacterial efficacy between any of the tannins could not be attributed to their functional group content or molar mass. Outer membrane disruption was not a significant factor in antibacterial efficacy of tannins against . In a hospital field study, draw patches coated with hydrolysable tannins and affixed to privacy curtains reduced total bacteria count by 60% over eight weeks compared to their matching uncoated reference sides. In a follow-up laboratory study with , very light spraying with water improved contact between bacteria and coating, enhancing the antibacterial effect by several orders of magnitude.

摘要

本研究的目标是为医院隐私帘的银基及其他现有抗菌解决方案开发一种可持续的、基于单宁的替代方案。对商业来源的树木单宁进行了表征，并测定了它们对[具体细菌名称1]和[具体细菌名称2]的体外抗菌性能。水解单宁显示出比缩合单宁更高的抗菌效力，但任何一种单宁之间的抗菌效力差异都不能归因于它们的官能团含量或摩尔质量。外膜破坏不是单宁对[具体细菌名称2]抗菌效力的重要因素。在一项医院现场研究中，与未涂覆的匹配参考面相比，涂覆有水解单宁并贴附在隐私帘上的拉片在八周内使细菌总数减少了60%。在一项针对[具体细菌名称2]的后续实验室研究中，用非常少量的水喷雾改善了细菌与涂层之间的接触，使抗菌效果提高了几个数量级。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4222/10144558/c78c84f385dd/jfb-14-00187-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4222/10144558/39e6d5e77870/jfb-14-00187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4222/10144558/21fc356c78f7/jfb-14-00187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4222/10144558/c624780cb40b/jfb-14-00187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4222/10144558/c78c84f385dd/jfb-14-00187-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4222/10144558/39e6d5e77870/jfb-14-00187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4222/10144558/21fc356c78f7/jfb-14-00187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4222/10144558/c624780cb40b/jfb-14-00187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4222/10144558/c78c84f385dd/jfb-14-00187-g005.jpg

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Front Microbiol. 2023 Jan 6;13:987164. doi: 10.3389/fmicb.2022.987164. eCollection 2022.
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Assessment of cleaning methods on bacterial burden of hospital privacy curtains: a pilot randomized controlled trial.
Infect Prev Pract. 2023 Jun 13;5(3):100291. doi: 10.1016/j.infpip.2023.100291. eCollection 2023 Sep.
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Sci Rep. 2021 Nov 8;11(1):21866. doi: 10.1038/s41598-021-01198-2.
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