Athanasiou Labrini V, Tsokana Constantina N, Doukas Dimitrios, Kantere Maria C, Katsoulos Panagiotis D, Papakonstantinou Georgios I, Katsogiannou Eleni G, Dedousi Anna
Clinic of Medicine, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, 43100 Karditsa, Greece.
Laboratory of Pathology, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, 43100 Karditsa, Greece.
Vet Sci. 2023 Mar 26;10(4):248. doi: 10.3390/vetsci10040248.
(1) Background: Rabbit hepatic coccidiosis, caused by , is a devastating disease with high morbidity and mortality rates. The disease is well described in rabbits, but little is known about infection in wild rabbits. In this study, we investigated the presence of infection in wild rabbits from the island of Lemnos, Greece, where this species is overpopulated, and the effects of infection on common hepatic biomarkers. (2) Methods: We used liver impression smears to detect the coccidian oocysts, and we defined the liver biochemical profile of the infected individuals. (3) Results: Overall, 13.3% of the liver imprints examined were positive for the presence of coccidial oocysts. The activities of liver enzymes, that is, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and glutamyltransferase (GGT), as well as globulins (GLOB), were increased while the concentrations of albumins (ALB), total proteins (TP) and the albumin to globulin (A/G) ratio were decreased in the infected individuals compared to the non-infected ones. (4) Conclusions: This study adds to the current knowledge on the pathogens affecting wild rabbits and those circulating in this population on the island of Lemnos, Greece. Moreover, we showed that infection exerts pathological effects on the hepatocyte integrity and liver function of wild rabbits, as reflected by the abnormal values of liver injury and dysfunction biomarkers.
(1) 背景：由[未提及具体病原体名称]引起的兔肝球虫病是一种发病率和死亡率都很高的毁灭性疾病。该病在家兔中已有详细描述，但对野兔感染[未提及具体病原体名称]的情况知之甚少。在本研究中，我们调查了希腊利姆诺斯岛野兔中[未提及具体病原体名称]感染的情况，该岛该物种数量过多，同时还研究了感染对常见肝脏生物标志物的影响。(2) 方法：我们使用肝脏印片检测球虫卵囊，并确定受感染个体的肝脏生化指标。(3) 结果：总体而言，所检查的肝脏印片中13.3%存在球虫卵囊呈阳性。与未感染个体相比，受感染个体的肝脏酶，即丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和谷氨酰转移酶（GGT）以及球蛋白（GLOB）的活性增加，而白蛋白（ALB）、总蛋白（TP）浓度以及白蛋白与球蛋白（A/G）比值降低。(4) 结论：本研究增加了目前关于影响野兔的病原体以及在希腊利姆诺斯岛该种群中传播的病原体的知识。此外，我们表明[未提及具体病原体名称]感染对野兔的肝细胞完整性和肝功能产生病理影响，这通过肝损伤和功能障碍生物标志物的异常值得以体现。
