Targeting Small-Conductance Calcium-Activated Potassium Channels in Atrial Fibrillation: Therapeutic Opportunities.
作者信息
Zhang Xiao-Dong, Chiamvimonvat Nipavan
机构信息
Division of Cardiovascular Medicine, Department of Internal Medicine (X.-D.Z., N.C.), School of Medicine, University of California, Davis.
Department of Pharmacology (N.C.), School of Medicine, University of California, Davis.
出版信息
Circ Res. 2023 Apr 28;132(9):1104-1106. doi: 10.1161/CIRCRESAHA.123.322777. Epub 2023 Apr 27.
Abstract
摘要
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本文引用的文献
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Enhanced Ca-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation.增强的 Ca2+依赖性 SK 通道门控和人心房颤动中的膜运输。
Circ Res. 2023 Apr 28;132(9):e116-e133. doi: 10.1161/CIRCRESAHA.122.321858. Epub 2023 Mar 17.
2
Highly accurate protein structure prediction with AlphaFold.利用 AlphaFold 进行高精度蛋白质结构预测。
Nature. 2021 Aug;596(7873):583-589. doi: 10.1038/s41586-021-03819-2. Epub 2021 Jul 15.
3
Small Conductance Ca-Activated K (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue.小电导钙激活钾（SK）通道mRNA在人心房和心室组织中的表达：供体、心房颤动和心力衰竭组织之间的比较。
Front Physiol. 2021 Apr 1;12:650964. doi: 10.3389/fphys.2021.650964. eCollection 2021.
4
Cardiac small-conductance calcium-activated potassium channels in health and disease.心脏小电导钙激活钾通道在健康和疾病中的作用。
Pflugers Arch. 2021 Mar;473(3):477-489. doi: 10.1007/s00424-021-02535-0. Epub 2021 Feb 23.
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First Clinical Study with AP30663 - a K 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation.AP30663 的首次临床研究 - 一种用于心房颤动转复的 K2 通道抑制剂正在研发中。
Clin Transl Sci. 2020 Nov;13(6):1336-1344. doi: 10.1111/cts.12835. Epub 2020 Jul 29.
6
Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.冷冻电镜结构解析人源 SK 钙调蛋白通道复合物的激活机制。
Science. 2018 May 4;360(6388):508-513. doi: 10.1126/science.aas9466.
7
Coupling of SK channels, L-type Ca channels, and ryanodine receptors in cardiomyocytes.心肌细胞中 SK 通道、L 型钙通道和兰尼碱受体的偶联。
Sci Rep. 2018 Mar 16;8(1):4670. doi: 10.1038/s41598-018-22843-3.
8
Contribution of small conductance K channels to sinoatrial node pacemaker activity: insights from atrial-specific Na /Ca exchange knockout mice.小电导钾通道对窦房结起搏活动的贡献：来自心房特异性钠/钙交换基因敲除小鼠的见解
J Physiol. 2017 Jun 15;595(12):3847-3865. doi: 10.1113/JP274249. Epub 2017 May 13.
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Cardiovasc Res. 2017 Mar 1;113(3):343-353. doi: 10.1093/cvr/cvx005.
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Small-conductance Ca2+ -activated K+ channels and cardiac arrhythmias.小电导钙激活钾通道与心律失常
Heart Rhythm. 2015 Aug;12(8):1845-51. doi: 10.1016/j.hrthm.2015.04.046. Epub 2015 May 5.
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