Department of Biotechnology, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, 517 502, Andhra, India.
Department of Zoology, Government Degree College, Anantapur, 515001, Andhra Pradesh, India.
Pharm Nanotechnol. 2023;11(5):433-446. doi: 10.2174/2211738511666230427145944.
Obesity is an immoderate or abnormal accretion of fat or adipose tissue in the body that is prone to damage the health of mankind. (Avocados) is a nutritious fruit known for its several health benefits. The current research was planned to evaluate the anti-obesity activity of bioengineered Silver Nanoparticles (AgNPs) against a high-fat diet (HFD) treated obese albino rats.
AgNPs were synthesized and characterized for the Phytochemical constituents, UV-vis Spectroscopy, FTIR, SEM and XRD. Furthermore, the lipid profile in serum, biochemical parameters and histopathological changes in tissues of albino rats were determined.
The present study revealed the presence of tannins, flavonoids, steroids and saponins, carbohydrates, alkaloids, phenols and glycosides. The peak was disclosed at 402 nm in UV-vis spectroscopy, confirming the synthesis of AgNPs. FTIR analysis showed two peaks at 3332.25 cm-1 which correspond to the O-H stretch of the carboxylic acid band, and 1636.40 cm-1 represents the N-H stretch of the amide of proteins, respectively. This result confirms their contribution to the capping and stabilization of AgNPs. The XRD results confirm the crystalline nature of AgNPs, and SEM results indicated that the synthesized AgNPs were spherical. Further, the results of the current study showed the improved lipid profile and biochemical parameters in rats supplemented with methanolic pulp extract of AgNPs when compared with other experimental groups. The histopathological findings displayed improved results with reduced hepatocyte degradation under the influence of AgNPs treatment.
All the experimental evidence indicated the possible anti-obesity effect of silver nanoparticles synthesized from the methanolic pulp extract of .
肥胖是指体内脂肪或脂肪组织过度或异常积聚，容易损害人类健康。（鳄梨）是一种营养丰富的水果，以其多种健康益处而闻名。本研究旨在评估生物工程银纳米粒子（AgNPs）对高脂肪饮食（HFD）处理肥胖白化大鼠的抗肥胖活性。
AgNPs 的合成和表征用于植物化学成分、紫外可见光谱、FTIR、SEM 和 XRD。此外，还测定了白化大鼠血清中的血脂谱、生化参数和组织学变化。
本研究表明存在单宁、类黄酮、甾醇和皂苷、碳水化合物、生物碱、酚类和糖苷。在紫外可见光谱中，在 402nm 处出现峰，证实了 AgNPs 的合成。FTIR 分析显示两个峰分别在 3332.25cm-1 处对应于羧酸带的 O-H 伸展，在 1636.40cm-1 处对应于蛋白质酰胺的 N-H 伸展。这一结果证实了它们对 AgNPs 的封端和稳定作用。XRD 结果证实了 AgNPs 的结晶性质，SEM 结果表明合成的 AgNPs 呈球形。此外，与其他实验组相比，用 AgNPs 甲醇浆提取物喂养的大鼠的血脂谱和生化参数得到了改善。组织病理学检查结果显示，在 AgNPs 治疗的影响下，肝细胞降解得到改善。
所有实验证据表明，由 甲醇浆提取物合成的银纳米粒子可能具有抗肥胖作用。
