Feier Horea, Grigorescu Andrei, Braescu Laurentiu, Falnita Lucian, Sintean Marius, Luca Constantin Tudor, Mocan Mihaela
Institute for Cardiovascular Diseases, 300310 Timisoara, Romania.
Department of Cardiology, University of Medicine and Pharmacy, 300041 Timisoara, Romania.
J Clin Med. 2023 Apr 13;12(8):2851. doi: 10.3390/jcm12082851.
(1) Background: Arterial cannulation in type A acute aortic dissection (TAAAD) is still subject to debate. We describe a systematic approach of using the innominate artery for arterial perfusion (2) Methods: The hospital records of 110 consecutive patients with acute TAAAD operated on between January 2014 and December 2022 were retrospectively analyzed. The effect of the cannulation site on early and late mortality, as well as on cardio-pulmonary perfusion indices (lactate and base excess levels, and cooling and rewarming speed) were investigated. (3) Results: There was a significant difference in early mortality (8.82% vs. 40.79%, < 0.01) but no difference in long-term survival beyond the first 30 days. Using the innominate artery enabled the use of approximately 20% higher CPB flows (2.73 ± 0.1 vs. 2.42 ± 0.06 L/min/m BSA, < 0.01), which resulted in more rapid cooling (1.89 ± 0.77 vs. 3.13 ± 1.62 min/°C/m BSA, < 0.01), rewarming (2.84 ± 1.36 vs. 4.22 ± 2.23, < 0.01), lower mean base excess levels during CPB (-5.01 ± 2.99 mEq/L vs. -6.66 ± 3.37 mEq/L, = 0.01) and lower lactate levels at the end of the procedure (4.02 ± 2.48 mmol/L vs. 6.63 ± 4.17 mmol/L, < 0.01). Postoperative permanent neurologic insult (3.12% vs. 20%, = 0.02) and acute kidney injury (3.12% vs. 32.81%, < 0.01) were significantly reduced. (4) Conclusions: systematic use of the innominate artery enables better perfusion and superior results in TAAAD repair.
(1) 背景:A型急性主动脉夹层(TAAAD)的动脉插管仍存在争议。我们描述了一种使用无名动脉进行动脉灌注的系统方法。(2) 方法:回顾性分析2014年1月至2022年12月期间连续接受手术的110例急性TAAAD患者的医院记录。研究插管部位对早期和晚期死亡率以及心肺灌注指标(乳酸和碱剩余水平、降温及复温速度)的影响。(3) 结果:早期死亡率存在显著差异(8.82% 对40.79%,<0.01),但30天以后的长期生存率无差异。使用无名动脉可使体外循环流量提高约20%(2.73±0.1对2.42±0.06L/min/m²体表面积,<0.01),这导致降温更快(1.89±0.77对3.13±1.62min/°C/m²体表面积,<0.01)、复温更快(2.84±1.36对4.22±2.23,<0.01),体外循环期间平均碱剩余水平更低(-5.01±2.99mEq/L对-6.66±3.37mEq/L,=0.01),手术结束时乳酸水平更低(4.02±2.48mmol/L对6.63±4.17mmol/L,<0.01)。术后永久性神经损伤(3.12%对20%,=0.02)和急性肾损伤(3.12%对32.81%,<0.01)显著减少。(4) 结论:在TAAAD修复中,系统使用无名动脉可实现更好的灌注并取得更好的结果。