Sacco Emilio, Marino Filippo, Gandi Carlo, Bientinesi Riccardo, Totaro Angelo, Moretto Stefano, Gavi Filippo, Campetella Marco, Racioppi Marco
Department of Urology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
J Clin Med. 2023 Apr 21;12(8):3021. doi: 10.3390/jcm12083021.
The artificial urinary sphincter (AUS) implantation is an effective treatment of post-prostatectomy urinary incontinence (PPI). Still, it may result in troublesome complications such as intraoperative urethral lesion and postoperative erosion. Based on the multilayered structure of the tunica albuginea of the corpora cavernosa, we evaluated an alternative transalbugineal surgical technique of AUS cuff placement with the aim to decrease perioperative morbidity while preserving the integrity of the corpora cavernosa. A retrospective study was conducted in a tertiary referral center from September 2012 to October 2021, including 47 consecutive patients undergoing AUS (AMS800) transalbugineal implantation. At a median (IQR) follow-up of 60 (24-84) months, no intraoperative urethral injury and only one noniatrogenic erosion occurred. The actuarial 12 mo and 5 yr overall erosion-free rates were 95.74% (95% CI: 84.04-98.92) and 91.76% (95% CI: 75.23-97.43), respectively. In preoperatively potent patients, the IIEF-5 score remained unchanged. The social continence (0-1 pads per day) rate was 82.98% (CI 95%: 68.83-91.10) at 12 mos and 76.81% (CI 95%: 60.56-87.04) at 5 yrs follow-up. Our technically refined approach to AUS implantation may help to avoid intraoperative urethral lesions and lower the risk of subsequent erosion without compromising sexual function in potent patients. Prospective and adequately powered studies are necessary to achieve more compelling evidence.
人工尿道括约肌(AUS)植入术是治疗前列腺切除术后尿失禁(PPI)的一种有效方法。然而,它可能会导致一些麻烦的并发症,如术中尿道损伤和术后侵蚀。基于阴茎海绵体白膜的多层结构,我们评估了一种替代的经白膜AUS袖带放置手术技术,旨在降低围手术期发病率,同时保持阴茎海绵体的完整性。2012年9月至2021年10月在一家三级转诊中心进行了一项回顾性研究,纳入了47例连续接受AUS(AMS800)经白膜植入术的患者。中位(IQR)随访60(24 - 84)个月时,未发生术中尿道损伤,仅发生1例非医源性侵蚀。12个月和5年的无侵蚀总发生率分别为95.74%(95%CI:84.04 - 98.92)和91.76%(95%CI:75.23 - 97.43)。术前有性功能的患者,国际勃起功能指数-5(IIEF-5)评分保持不变。12个月时社会控尿(每天0 - 1片尿垫)率为82.98%(95%CI:68.83 - 91.10),5年随访时为76.81%(95%CI:60.56 - 87.04)。我们技术精湛的AUS植入方法可能有助于避免术中尿道损伤,并降低后续侵蚀的风险,同时不损害有性功能患者的性功能。需要进行前瞻性且样本量充足的研究以获得更有说服力的证据。