通过生物信息学方法对GHBh1受体假定的结构和功能特性的概述。

An Overview of the Putative Structural and Functional Properties of the GHBh1 Receptor through a Bioinformatics Approach.

作者信息

Wolf Casper J H, Venselaar Hanka, Spoelder Marcia, Beurmanjer Harmen, Schellekens Arnt F A, Homberg Judith R

机构信息

Department of Psychiatry, Radboudumc, 6525 GC Nijmegen, The Netherlands.

Department of Cognitive Neuroscience, Donders Institute for Brain Cognition and Behaviour, Radboudumc, 6525 EN Nijmegen, The Netherlands.

出版信息

Life (Basel). 2023 Mar 31;13(4):926. doi: 10.3390/life13040926.

DOI:10.3390/life13040926

PMID:37109455

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10142108/

Abstract

The neurotransmitter γ-hydroxybutyric acid (GHB) is suggested to be involved in neuronal energy homeostasis processes, but the substance is also used as a recreational drug and as a prescription medication for narcolepsy. GHB has several high-affinity targets in the brain, commonly generalized as the GHB receptor. However, little is known about the structural and functional properties of GHB receptor subtypes. This opinion article discusses the literature on the putative structural and functional properties of the GHBh1 receptor subtype. GHBh1 contains 11 transmembrane helices and at least one intracellular intrinsically disordered region (IDR). Additionally, GHBh1 shows a 100% overlap in amino acid sequence with the Riboflavin (vitamin B2) transporter, which opens the possibility of a possible dual-function (transceptor) structure. Riboflavin and GHB also share specific neuroprotective properties. Further research into the GHBh1 receptor subtype may pave the way for future therapeutic possibilities for GHB.

摘要

神经递质γ-羟基丁酸（GHB）被认为参与神经元能量稳态过程，但该物质也被用作消遣性药物和发作性睡病的处方药。GHB在大脑中有几个高亲和力靶点，通常统称为GHB受体。然而，关于GHB受体亚型的结构和功能特性知之甚少。这篇观点文章讨论了关于GHBh1受体亚型假定的结构和功能特性的文献。GHBh1包含11个跨膜螺旋和至少一个细胞内固有无序区域（IDR）。此外，GHBh1与核黄素（维生素B2）转运体的氨基酸序列有100%的重叠，这开启了其具有双功能（转ceptor）结构的可能性。核黄素和GHB也具有特定的神经保护特性。对GHBh1受体亚型的进一步研究可能为GHB未来的治疗可能性铺平道路。