Kedžo Josip, Lovrić Kojundžić Sanja, Marinović Guić Maja, Tandara Leida, Brešković Toni, Jurišić Zrinka
Department of Cardiology, University Hospital of Split, 21000 Split, Croatia.
Department of Diagnostic and Interventional Radiology, University Hospital of Split, 21000 Split, Croatia.
Life (Basel). 2023 Apr 3;13(4):935. doi: 10.3390/life13040935.
The association of atrial fibrillation (AF) and brain perfusion (BP) has not been well-defined. This study aimed to determine the association of persistent AF with BP and cognition, in comparison to control subjects and with regards to electrical cardioversion (ECV).
This study compared 25 patients with persistent AF undergoing elective ECV with 16 age/sex-matched controls. We measured regional BP by using the magnetic resonance (MRI) arterial spin labelling technique. Cognitive function was assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) cognitive function index. Measurements were performed at baseline and 6 weeks after ECV.
There was no significant difference in BP between AF patients and control subjects ( > 0.05). Following the ECV, there was a significant improvement in BP in 15 patients who maintained sinus rhythm, while there was no significant change in the recurrence group (297 ± 24 before vs. 328 ± 37 after ECV, = 0.008, and 297 ± 22 before vs. 307 ± 24 after ECV, = 0.45, respectively). There was no difference in the cognitive assessment between AF patients and control subjects, as well as before and after ECV within the AF group (52.2 ± 9.6 vs. 51.2 ± 6.2, = 0.71 and 53 ± 10 vs. 54 ± 9, = 0.46, respectively).
This study did not show difference in BP between persistent AF patients and matched control subjects. Restoration of sinus rhythm was associated with significantly improved BP. There was no association of ECV and changes in cognitive function.
心房颤动（AF）与脑灌注（BP）之间的关联尚未明确界定。本研究旨在确定持续性AF与BP及认知之间的关联，并与对照组进行比较，同时探讨电复律（ECV）的影响。
本研究将25例接受择期ECV的持续性AF患者与16例年龄/性别匹配的对照组进行比较。我们使用磁共振（MRI）动脉自旋标记技术测量局部BP。使用患者报告结局测量信息系统（PROMIS）认知功能指数评估认知功能。在基线和ECV后6周进行测量。
AF患者与对照组之间的BP无显著差异（>0.05）。ECV后，15例维持窦性心律的患者BP有显著改善，而复发性组无显著变化（ECV前297±24 vs. ECV后328±37， = 0.008；ECV前297±22 vs. ECV后307±24， = 0.45）。AF患者与对照组之间的认知评估无差异，AF组内ECV前后也无差异（分别为52.2±9.6 vs. 51.2±6.2， = 0.71；53±10 vs. 54±9， = 0.46）。
本研究未显示持续性AF患者与匹配对照组之间的BP存在差异。窦性心律的恢复与BP显著改善相关。ECV与认知功能变化无关联。
