通过参与反式取代硝基乙烯的环加成反应，全区域和立体选择性合成新型烟碱类化合物的新方法：全面的实验和 MEDT 研究。
Full Regio- and Stereoselective Protocol for the Synthesis of New Nicotinoids via Cycloaddition Processes with the Participation of Trans-Substituted Nitroethenes: Comprehensive Experimental and MEDT Study.
机构信息
Department of Organic Chemistry and Technology, Cracow University of Technology, Warszawska 24, 31-155 Krakow, Poland.
Faculty of Medicine, The John Paul II Catholic University of Lublin, Konstantynow 1J, 20-708 Lublin, Poland.
出版信息
Molecules. 2023 Apr 17;28(8):3535. doi: 10.3390/molecules28083535.
[3 + 2] Cycloaddition reactions with the participation of -C-(3-pyridyl)--methylnitrone and series of -2-R-nitroethenes were both experimentally and theoretically explored in the framework of Molecular Electron Density Theory. It was found that all considered processes are realized under mild conditions and in full regio- and stereocontrol. The ELF analysis additionally showed that the studied reaction proceeds by a two-stage, one-step mechanism.
[3 + 2]环加成反应与-C-(3-吡啶基)--甲基亚硝酮和一系列-2-R-硝基亚乙烯基的参与，在分子电子密度理论框架内进行了实验和理论探索。结果表明，所有考虑的过程都是在温和的条件下，完全区域和立体控制下实现的。ELF 分析还表明，所研究的反应通过两步一步机制进行。
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