银促进的自由基级联反应：2-烯丙氧基苯甲醛的芳基二氟甲基化/环化反应，用于合成 3-芳基二氟甲基色满-4-酮衍生物。

Department of Chemistry, Shanghai University, Shanghai 200444, China.

Laboratory for Microstructures, Shanghai University, Shanghai 200444, China.

Molecules. 2023 Apr 19;28(8):3578. doi: 10.3390/molecules28083578.

A convenient silver-promoted radical cascade aryldifluoromethylation/cyclization of 2-allyloxybenzaldehydes has been developed. Experimental studies disclosed that the addition of aryldifluoromethyl radicals in situ produced from easily accessible -difluoroarylacetic acids to unactivated double bonds in 2-allyloxybenzaldehyde was an effective route to access a series of 3-aryldifluoromethyl-containing chroman-4-one derivatives in moderate to good yields under mild reaction conditions.

一种方便的银促进的自由基级联芳基二氟甲基化/环化反应已经被开发出来。实验研究表明，通过易得的 -二氟芳基乙酸原位产生的芳基二氟甲基自由基与 2-烯丙氧基苯甲醛中的未活化双键加成，是在温和反应条件下以中等至良好收率获得一系列 3-芳基二氟甲基色满-4-酮衍生物的有效途径。