蓝光促进芳基酮的二氟烷基化反应：季碳二氟烷基化合物和四取代单氟烯烃的合成
Blue Light Promoted Difluoroalkylation of Aryl Ketones: Synthesis of Quaternary Alkyl Difluorides and Tetrasubstituted Monofluoroalkenes.
作者信息
Li Kangkui, Chen Jingchao, Yang Chunhui, Zhang Keyang, Pan Chunxiang, Fan Baomin
机构信息
Key Laboratory of Chemistry in Ethnic Medicinal Resources (Yunnan Minzu University), State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, Yunnan China.
School of Chemistry and Environment, Yunnan Minzu University, Kunming 650031, Yunnan China.
出版信息
Org Lett. 2020 Jun 5;22(11):4261-4265. doi: 10.1021/acs.orglett.0c01294. Epub 2020 May 14.
A facile and cost-effective method for the preparation of fluoroalkylated compounds has been described by the direct photoexcitation of halofluoroalkanes with blue light absorptivity, enabling the difluoroalkylation of aryl ketones. The methodology has provided an efficient, mild, and catalyst-free synthetic method for quaternary difluoroalkylated arenes and tetrasubstituted monofluoroalkenes.
一种通过对具有蓝光吸收性的卤代氟烷进行直接光激发来制备氟烷基化化合物的简便且经济高效的方法已被报道，该方法能够实现芳基酮的二氟烷基化。该方法为季二氟烷基化芳烃和四取代单氟烯烃提供了一种高效、温和且无催化剂的合成方法。
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