Wang Lei, Oh Jae-Young, Yang Hye-Won, Hyun Jimin, Ahn Ginnae, Fu Xiaoting, Xu Jiachao, Gao Xin, Cha Seon-Heui, Jeon You-Jin
College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Food Safety and Processing Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea.
Polymers (Basel). 2023 Apr 17;15(8):1912. doi: 10.3390/polym15081912.
Our previous studies have evaluated the bioactivities of a fucoidan isolated from (SF-F). To further investigate the health benefit of SF-F, in the present study, the protective effect of SF-F against ethanol (EtOH)-induced oxidative damage has been evaluated in in vitro and in vivo models. SF-F effectively improved the viability of EtOH-treated Chang liver cells by suppressing apoptosis. In addition, the in vivo test results indicate that SF-F significantly and dose-dependently increased the survival rate of zebrafish treated with EtOH. Further research results show that this action works through decreasing cell death via reduced lipid peroxidation by scavenging intracellular reactive oxygen species in EtOH-stimulated zebrafish. These results indicate that SF-F effectively protected Chang liver cells and zebrafish against EtOH-induced oxidative damage and suggest the potential of SF-F to be used as an ingredient in the functional food industry.
我们之前的研究已经评估了从……中分离出的一种岩藻多糖（SF-F）的生物活性。为了进一步研究SF-F对健康的益处，在本研究中，已在体外和体内模型中评估了SF-F对乙醇（EtOH）诱导的氧化损伤的保护作用。SF-F通过抑制细胞凋亡有效提高了经乙醇处理的 Chang 肝细胞的活力。此外，体内试验结果表明，SF-F显著且剂量依赖性地提高了经乙醇处理的斑马鱼的存活率。进一步的研究结果表明，这种作用是通过清除乙醇刺激的斑马鱼细胞内的活性氧来减少脂质过氧化，从而降低细胞死亡。这些结果表明，SF-F能有效保护 Chang 肝细胞和斑马鱼免受乙醇诱导的氧化损伤，并表明SF-F有潜力用作功能性食品工业的一种成分。
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