Ali Md Zeeshan, Bilgrami Anwar L, Ahsan Jawaid
Drosophila Behavior Laboratory, Department of Biotechnology, Central University of South Bihar, Gaya 824236, Bihar, India.
Deanship of Scientific Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Toxics. 2023 Mar 30;11(4):327. doi: 10.3390/toxics11040327.
Millions of people in developing countries are affected by arsenic (As) toxicity and its prevalence. Arsenic's detrimental effects on humans have been amplified by an unacceptable level of exposure to food and drinking water, the ongoing rise in industrial usage, and several other occupational conditions. Due to increased cellular absorption and the ability to cross the blood-brain barrier (BBB), inorganic arsenic (iAs) is extremely hazardous to living organisms in its trivalent form. Arsenic toxicity damages an organism's tissues and organs, resulting in skin cancer, circulatory system abnormalities, and central nervous system disorders. However, a competent model system is required to investigate the acute effects of arsenic on the brain, cognition ability, and to assess any behavioral impairment. Hence, , with its short generation time, genomic similarities with humans, and its availability for robust behavioral paradigms, may be considered an ideal model for studying arsenic toxicity. The present study helps to understand the toxic effects of acute arsenic treatment on the behavior, cognition, and development of in a time-dependent manner. We found that the exposure of fruit flies to arsenic significantly affected their locomotor abilities, pupae size, cognitive functions, and neurobehavioral impairment. Hence, providing a better understanding of how arsenic toxicity affects the brain leading to acute behavioral disorders and neurological alterations, this study will lead to a better understanding of the mechanisms.
发展中国家数以百万计的人受到砷（As）毒性及其流行的影响。食物和饮用水中不可接受的砷暴露水平、工业用途的持续增加以及其他一些职业条件，加剧了砷对人类的有害影响。由于细胞吸收增加以及能够穿过血脑屏障（BBB），无机砷（iAs）的三价形式对生物体极其有害。砷中毒会损害生物体的组织和器官，导致皮肤癌、循环系统异常和中枢神经系统紊乱。然而，需要一个合适的模型系统来研究砷对大脑、认知能力的急性影响，并评估任何行为损伤。因此，由于其世代时间短、与人类的基因组相似性以及可用于强大的行为范式，果蝇可能被认为是研究砷毒性的理想模型。本研究有助于及时了解急性砷处理对果蝇行为、认知和发育的毒性作用。我们发现，果蝇接触砷会显著影响其运动能力、蛹大小、认知功能和神经行为损伤。因此，本研究有助于更好地理解砷毒性如何影响大脑，导致急性行为障碍和神经改变，将有助于更好地理解其机制。
