Lei Pengyu, Zhang Wenxia, Ma Jiahui, Xia Yuping, Yu Haiyang, Du Jiao, Fang Yimeng, Wang Lei, Zhang Kun, Jin Libo, Sun Da, Zhong Junbo
Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou 325035, China.
Department of Burn and Plastic Surgery, Zigong Fourth People's Hospital, Zigong 643099, China.
Toxics. 2023 Apr 17;11(4):380. doi: 10.3390/toxics11040380.
A large amount of nano-/microparticles (MNPs) are released into water, not only causing severe water pollution, but also negatively affecting organisms. Therefore, it is crucial to evaluate MNP toxicity and mechanisms in water. There is a significant degree of similarity between the genes, the central nervous system, the liver, the kidney, and the intestines of zebrafish and the human body. It has been shown that zebrafish are exceptionally suitable for evaluating the toxicity and action mechanisms of MNPs in water on reproduction, the central nervous system, and metabolism. Providing ideas and methods for studying MNP toxicity, this article discusses the toxicity and mechanisms of MNPs from zebrafish.
大量的纳米/微粒（MNPs）被排放到水中，不仅造成严重的水污染，还会对生物体产生负面影响。因此，评估水中MNPs的毒性及其作用机制至关重要。斑马鱼的基因、中枢神经系统、肝脏、肾脏和肠道与人体有很大程度的相似性。研究表明，斑马鱼非常适合用于评估水中MNPs对生殖、中枢神经系统和新陈代谢的毒性及作用机制。本文从斑马鱼的角度探讨MNPs的毒性及其作用机制，为研究MNPs毒性提供思路和方法。
