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检测来自哺乳期母亲的母乳和血清样本中针对 SARS-CoV-2 结构蛋白的 IgA 和 IgG 抗体。

Detection of IgA and IgG Antibodies against the Structural Proteins of SARS-CoV-2 in Breast Milk and Serum Samples Derived from Breastfeeding Mothers.

机构信息

Laboratorio de Inmunobiología y Diagnóstico Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo de los Bravo 39086, Mexico.

Unidad de Investigación en Inmunología y Proteómica, Laboratorio de Investigación en COVID-19, Hospital Infantil de México "Federico Gómez", Mexico City 06720, Mexico.

出版信息

Viruses. 2023 Apr 14;15(4):966. doi: 10.3390/v15040966.

DOI:10.3390/v15040966
PMID:37112946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10144911/
Abstract

COVID-19 vaccination or natural infection is associated with the development of immunity. The search of IgA and IgG antibodies against all the structural proteins (spike, nucleocapsid, membrane, and envelope) of SARS-CoV-2 in breastfeeding mothers is associated with immunity that can help the newborn avoid development of the infection. In this study, we analyzed 30 breastfeeding women that provided samples of breast milk and serum and evaluated the presence of IgA, total IgG, and subclasses against the structural proteins of SARS-CoV-2. We reported a high seroprevalence to IgA (76.67-100%) and negativity to IgG against all analyzed proteins in breast milk. Seroprevalence in serum samples was around 10-36.67% to IgA and 23.3-60% to IgG. Finally, we detected the presence of the subclasses IgG1, IgG2, and IgG4 against all the structural proteins of SARS-CoV-2. This work provides evidence of the presence of IgA and IgG antibodies against the four structural proteins of SARS-CoV-2 in breast milk and serum samples derived from breastfeeding women, which can confer immunity to the newborn.

摘要

COVID-19 疫苗接种或自然感染会引发免疫反应。对 SARS-CoV-2 的所有结构蛋白（刺突蛋白、核衣壳蛋白、膜蛋白和包膜蛋白）的 IgA 和 IgG 抗体的检测与能够帮助新生儿避免感染的免疫反应有关。在这项研究中，我们分析了 30 位提供母乳和血清样本的哺乳期妇女，评估了针对 SARS-CoV-2 结构蛋白的 IgA、总 IgG 和亚类的存在情况。我们报告了针对 IgA 的高血清阳性率（76.67-100%）和针对所有分析的乳蛋白 IgG 的阴性。血清样本中针对 IgA 的血清阳性率约为 10-36.67%，针对 IgG 的血清阳性率约为 23.3-60%。最后，我们检测到针对 SARS-CoV-2 的所有结构蛋白的 IgG1、IgG2 和 IgG4 亚类的存在。这项工作提供了证据表明，针对 SARS-CoV-2 的四个结构蛋白的 IgA 和 IgG 抗体存在于来自哺乳期妇女的母乳和血清样本中，这可以为新生儿提供免疫力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f9f/10144911/dbab8423f114/viruses-15-00966-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f9f/10144911/198abcb8b379/viruses-15-00966-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f9f/10144911/a273396bea1f/viruses-15-00966-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f9f/10144911/dbab8423f114/viruses-15-00966-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f9f/10144911/198abcb8b379/viruses-15-00966-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f9f/10144911/a273396bea1f/viruses-15-00966-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f9f/10144911/dbab8423f114/viruses-15-00966-g003.jpg

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[1]
Detection of IgA and IgG Antibodies against the Structural Proteins of SARS-CoV-2 in Breast Milk and Serum Samples Derived from Breastfeeding Mothers.

Viruses. 2023-4-14

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引用本文的文献

[1]
SARS-CoV-2 antibodies in breast milk of women given one & two doses of COVID-19 vaccine.

Indian J Med Res. 2024-11

本文引用的文献

[1]
Development of SARS-CoV-2 specific IgG and IgA antibodies in serum and milk with different SARS-COV-2 vaccines in lactating women.

Int Breastfeed J. 2023-1-11

[2]
Clinical features and severe acute respiratory syndrome-coronavirus-2 structural protein-based serology of Mexican children and adolescents with coronavirus disease 2019.

PLoS One. 2022

[3]
The kinetics of IgG subclasses and contributions to neutralizing activity against SARS-CoV-2 wild-type strain and variants in healthy adults immunized with inactivated vaccine.

Immunology. 2022-10

[4]
Changes in Anti-SARS-CoV-2 IgG Subclasses over Time and in Association with Disease Severity.

Viruses. 2022-4-29

[5]
COVID-19 Neutralizing Antibodies in Breast Milk of Mothers Vaccinated with Three Different Vaccines in Mexico.

Vaccines (Basel). 2022-4-18

[6]
Anti-SARS-CoV-2 IgA and IgG in human milk after vaccination is dependent on vaccine type and previous SARS-CoV-2 exposure: a longitudinal study.

Genome Med. 2022-4-21

[7]
IgG and IgA Antibodies Post SARS-CoV-2 Vaccine in the Breast Milk and Sera of Breastfeeding Women.

Vaccines (Basel). 2022-1-16

[8]
Mother-to-Child Signaling through Breast Milk Biomolecules.

Biomolecules. 2021-11-23

[9]
Antibodies specific to SARS-CoV-2 proteins N, S and E in COVID-19 patients in the normal population and in historical samples.

J Gen Virol. 2021-11

[10]
COVID-19 mRNA Vaccination in Lactation: Assessment of Adverse Events and Vaccine Related Antibodies in Mother-Infant Dyads.

Front Immunol. 2021

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