Verheugt F W, van Noord-Bokhorst J C, von dem Borne A E, Engelfriet C P
Vox Sang. 1979;36(1):1-8. doi: 10.1111/j.1423-0410.1979.tb04390.x.
A family is presented, in which the mother developed strong neutrophil granulocyte-specific antibodies with the specificity anti-NA. The first and third children, both NA1-positive, suffered from severe transient neonatal neutropenia, but the second child, NA1-negative, did not. Anti-NA1 antibodies were detectable in the serum of one affected child and the antibody level was directly related to the extent of neutropenia. The incidence of granulocyte-specific antibodies in 198 pregnant women was determined and found to be low.
本文报道了一个家庭，其中母亲产生了具有抗NA特异性的强效中性粒细胞特异性抗体。第一个和第三个孩子均为NA1阳性，患有严重的短暂性新生儿中性粒细胞减少症，而第二个孩子为NA1阴性，则未患病。在一名患病儿童的血清中可检测到抗NA1抗体，且抗体水平与中性粒细胞减少的程度直接相关。测定了198名孕妇中粒细胞特异性抗体的发生率，发现其发生率较低。
